3-isobutyl-8-pyrrolidinoxanthine

Known as: IPDX cpd

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.

2008

2008

Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines.

Sergey Ryzhov, Rinat Zaynagetdinov, +4 authors I. A. Feoktistov
The Journal of pharmacology and experimental…
2008

Pharmacological studies suggest that A(2B) adenosine receptors mediate proinflammatory effects of adenosine. This concept was… (More)

Is this relevant?

Highly Cited

2004

Highly Cited

2004

Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.

Sergey Ryzhov, Anna E. Goldstein, Anton G Matafonov, Dewan Zeng, Italo Biaggioni, I. A. Feoktistov
Journal of immunology
2004

Adenosine provokes bronchoconstriction in asthmatics through acute activation of mast cells, but its potential role in chronic… (More)

Is this relevant?

2003

2003

A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.

Colleen M Woods, James Toouli, G. T. P. Saccone
British journal of pharmacology
2003

1. The aim of this study was to define the P1 purinergic receptors that regulate spontaneous or adenosine-induced duodenal motor… (More)

Is this relevant?

2001

2001

Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).

I. A. Feoktistov, Elizabeth M. Garland, +4 authors Italo Biaggioni
Biochemical pharmacology
2001

The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure… (More)

Is this relevant?

2001

2001

Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.

Maria B Grant, Michael Davis, Susana Josefina Caballero, I. A. Feoktistov, Italo Biaggioni, Luiz Belardinelli
Investigative ophthalmology & visual science
2001

PURPOSE The nucleoside adenosine has been implicated in angiogenesis. A previous study demonstrated that activation of the A(2B… (More)

Is this relevant?

2001

2001

Adenosine receptor antagonists and retinal neovascularization in vivo.

R P Mino, Peter Spörri, +4 authors M. A. B. Grant
Investigative ophthalmology & visual science
2001

PURPOSE The role of adenosine receptor (AdoR) antagonists in human retinal endothelial cell function in vitro has previously been… (More)

Is this relevant?