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3-isobutyl-8-pyrrolidinoxanthine

Known as: IPDX cpd 
 
National Institutes of Health

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2 relations

Broader (2)

PyrrolidinonesXanthines

Papers overview

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Highly Cited
2008
Highly Cited
2008
Effect of A2B Adenosine Receptor Gene Ablation on Adenosine-Dependent Regulation of Proinflammatory Cytokines
Pharmacological studies suggest that A2B adenosine receptors mediate proinflammatory effects of adenosine. This concept was… Expand
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Highly Cited
2004
Highly Cited
2004
Adenosine-Activated Mast Cells Induce IgE Synthesis by B Lymphocytes: An A2B-Mediated Process Involving Th2 Cytokines IL-4 and IL-13 with Implications for Asthma12
Adenosine provokes bronchoconstriction in asthmatics through acute activation of mast cells, but its potential role in chronic… Expand
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2003
2003
A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.
1. The aim of this study was to define the P1 purinergic receptors that regulate spontaneous or adenosine-induced duodenal motor… Expand
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2001
2001
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).
The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure… Expand
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Highly Cited
2001
Highly Cited
2001
Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.
PURPOSE The nucleoside adenosine has been implicated in angiogenesis. A previous study demonstrated that activation of the A(2B… Expand
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2001
2001
Adenosine receptor antagonists and retinal neovascularization in vivo.
PURPOSE The role of adenosine receptor (AdoR) antagonists in human retinal endothelial cell function in vitro has previously been… Expand
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