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3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

Known as: 3alpha-Hydroxysteroid Dehydrogenase (B-specific), 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) [Chemical/Ingredient], 3 alpha-Hydroxysteroid Dehydrogenase (B-Specific) 
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA… 
National Institutes of Health

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11 relations

Narrower (1)

5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
DHRS9 geneDHRS9 protein, humanIn BloodProcess of secretion

Papers overview

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Highly Cited
2003
Highly Cited
2003
Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells.
The role of IGF-I in Leydig cell maturation was studied by evaluation of: 1) steady state levels for nine mRNA species expressed… 
Highly Cited
1998
Highly Cited
1998
Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD, E.C. 1.1.1.213, AKR1C9) is a member of the aldo-keto reductase (AKR… 
Highly Cited
1996
Highly Cited
1996
Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis.
BACKGROUND & AIMS The molecular regulation of hepatic bile acid transporters during cholestasis is largely unknown. Cloning of… 
Highly Cited
1995
Highly Cited
1995
Substrate Specificity, Gene Structure, and Tissue-specific Distribution of Multiple Human 3α-Hydroxysteroid Dehydrogenases (*)
We have expressed in Escherichia coli functionally active proteins encoded by two human cDNAs that were isolated previously by… 
Highly Cited
1995
Highly Cited
1995
Effects of luteinizing hormone (LH) and androgen on steady state levels of messenger ribonucleic acid for LH receptors, androgen receptors, and steroidogenic enzymes in rat Leydig cell progenitors in…
Adult Leydig cells differentiate postnatally from mesenchymal-like progenitor cells. The relative scarcity of LH receptors (LHRs… 
Highly Cited
1994
Highly Cited
1994
Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase.
Rat liver cytosol has been found to reduce dehydroascorbic acid (DHAA) to ascorbic acid in the presence of NADPH. The enzyme… 
Review
1993
Review
1993
Androgen and progesterone metabolism in the central and peripheral nervous system
Highly Cited
1993
Highly Cited
1993
Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.
The activities of the 5 alpha-reductase [the enzyme that converts testosterone into dihydrotestosterone (DHT)] and 3 alpha… 
Highly Cited
1991
Highly Cited
1991
Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Review
1978
Review
1978
Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile.
A review of the 3 alpha-hydroxysteroid dehydrogenase method for determining the concentration of total bile acids in bile is… 
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