Skip to search formSkip to main contentSkip to account menu

3,4-dimethyl-2,5-hexanedione

National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Hexanones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy.
Several widely used aromatic hydrocarbon solvents reportedly induce blue-green discoloration of tissues and urine in animals and… 
1992
1992
Effect of 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione on retrograde axonal transport in sciatic nerve
The effects of systemically introduced neurotoxic solvents 2,5-hexanedione (2,5-HD) and 3,4-dimethyl-2,5-hexanedione (DMHD) on… 
1990
1990
Effects of neurofilamentous axonopathy-producing neurotoxicants on in vitro production of ATP by brain mitochondria
1989
1989
Hexanedione effects on protein phosphorylation in rat peripheral nerve
Highly Cited
1987
Highly Cited
1987
2,5-Hexanedione alters microtubule assembly. I. Testicular atrophy, not nervous system toxicity, correlates with enhanced tubulin polymerization.
Highly Cited
1987
Highly Cited
1987
2,5-Hexanedione alters microtubule assembly. II. Enhanced polymerization of crosslinked tubulin.
Highly Cited
1984
Highly Cited
1984
In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy.
We have postulated that the toxic neuropathies associated with neurofilament-filled axonal swellings have a common pathogenesis… 
Highly Cited
1983
Highly Cited
1983
The Spatio‐Temporal Pattern of the Axonopathy Associated with the Neurotoxicity of 3,4‐Dimethyl-2,5‐Hexanedione in the Rat
The neurotoxicity of the γ-diketone 3,4-dimethyl-2,5-hexanedione(DMHD) was studied to determine the distribution of the… 
Highly Cited
1983
Highly Cited
1983
The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings.
Highly Cited
1983
Highly Cited
1983
The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)