24(S),25-epoxycholesterol

The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA… Expand

Mast cell is one of the central effectors in inflammatory responses. Recent studies suggest that a promising therapeutic approach… Expand

The oxysterol 24(S),25-epoxycholesterol is made in a shunt in the cholesterol biosynthetic pathway in all cholesterogenic cells… Expand

Liver X receptor (LXR) activation represents a mechanism to prevent macrophage foam cell formation. Previously, we demonstrated… Expand

The effects of oxysterol and drug ligands of the liver X receptor (LXR) on cytochrome P450 expression were evaluated in primary… Expand

Abstract— Oxysterols are key regulators of lipid metabolism and regulate gene expression by activating the liver X receptor (LXR… Expand

Efforts to improve the synthesis of 24(S),25-epoxycholesterol (1) from stigmasterol (3) have included identification of 6 alpha… Expand

Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important… Expand

Biosynthetically tritiated sterols from Chinese hamster lung (Dede) cells were fractionated by high performance liquid… Expand

Previously we showed that 24(S),25-epoxycholesterol is formed from acetate, via squalene 2,3(S),22(S),23-dioxide and 24(S),25… Expand