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24(S),25-epoxycholesterol

National Institutes of Health

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24,25-epoxycholesterol

Papers overview

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2019
2019
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA… 
Review
2009
Review
2009
24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis.
  • Andrew J. Brown
  • The international journal of biochemistry & cell…
  • 2009
  • Corpus ID: 6814913
Highly Cited
2007
Highly Cited
2007
Selective Up-regulation of LXR-regulated Genes ABCA1, ABCG1, and APOE in Macrophages through Increased Endogenous Synthesis of 24(S),25-Epoxycholesterol*
Liver X receptor (LXR) activation represents a mechanism to prevent macrophage foam cell formation. Previously, we demonstrated… 
2007
2007
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.
Highly Cited
2004
Highly Cited
2004
CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.
The effects of oxysterol and drug ligands of the liver X receptor (LXR) on cytochrome P450 expression were evaluated in primary… 
Highly Cited
2003
Highly Cited
2003
Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation
Abstract— Oxysterols are key regulators of lipid metabolism and regulate gene expression by activating the liver X receptor (LXR… 
2000
2000
Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol.
Efforts to improve the synthesis of 24(S),25-epoxycholesterol (1) from stigmasterol (3) have included identification of 6 alpha… 
Highly Cited
1986
Highly Cited
1986
24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase.
Highly Cited
1985
Highly Cited
1985
Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts.
Highly Cited
1985
Highly Cited
1985
24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis.
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