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Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
TLDR
It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro. Expand
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
TLDR
The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers. Expand
The glial nature of embryonic and adult neural stem cells.
TLDR
The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated. Expand
Long-distance neuronal migration in the adult mammalian brain.
TLDR
Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb. Expand
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.
TLDR
It is shown that SVZ B1 cells in adult mice extend a minute apical ending to directly contact the ventricle and a long basal process ending on blood vessels, significantly reshaping the understanding of this adult neurogenic niche. Expand
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
TLDR
It is shown that transit-amplifying C cells retain stem cell competence under the influence of growth factors and are 53-fold enriched for neurosphere generation. Expand
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain
TLDR
The number of oligodendrocytes derived from type B cells in vivo increased fourfold after a demyelinating lesion in corpus callosum, indicating that SVZ astrocyes participate in myelin repair in the adult brain. Expand
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
TLDR
It is shown that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells. Expand
Mosaic Organization of Neural Stem Cells in the Adult Brain
TLDR
It is shown that postnatal stem cells in different regions produce different types of neurons, even when heterotopically grafted or grown in culture, which suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors. Expand
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.
TLDR
It is demonstrated that LGE and MGE cells migrate along different routes to populate distinct regions in the developing brain, and it is shown that the MGE is a major source of neurons migrating dorsally and invading the developing neocortex. Expand
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