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21-hydroxy-6,19-oxidoprogesterone

Known as: 21-hydroxy-6,19-epoxyprogesterone, 21OH-6,19OP, 21OH-6OP 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Progesterone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
21-Hydroxy-6,19-epoxyprogesterone: A Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action.
Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR… 
Review
2017
Review
2017
21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action.
Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR… 
2014
2014
The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy.
2010
2010
Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids
Background The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent… 
2008
2008
Exploring the molecular basis of action of the passive antiglucocorticoid 21-hydroxy-6,19-epoxyprogesterone.
21-Hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a selective antiglucocorticoid that lacks the bulky substituent at C-11 found… 
2008
2008
Hemisuccinate of 21‐Hydroxy‐6,19‐Epoxyprogesterone: A Tissue‐Specific Modulator of the Glucocorticoid Receptor
The introduction of a hemisuccinate group at the 21‐position of the passive antiglucocorticoid 21OH‐6,19OP leads to a compound… 
Highly Cited
2003
Highly Cited
2003
Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast…
Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. We reported previously that cortisol… 
2001
2001
A process for preparing 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP)
2001
2001
A process for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP)
1997
1997
21-Hydroxy-6,19-oxidoprogesterone: a novel synthetic steroid with specific antiglucocorticoid properties in the rat.
In the rat, the conformationally highly bent steroid 21-hydroxy-6, 19-oxidoprogesterone efficiently displaces [3H]corticosterone… 
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