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20-alpha-Dihydroprogesterone

Known as: 20-alpha-Hydroxyprogesterone, Pregn-4-en-3-one, 20-alpha-hydroxy-, 20alpha Hydroxypregn 4 Ene 3 One 
A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20… Expand
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (1)

3-hydroxypregn-4-en-20-one
In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (2)

ProgesteroneProgestins

Papers overview

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Highly Cited
2007
Highly Cited
2007
Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: A multimodal analysis
One important complication of diabetes is damage to the peripheral nervous system. However, in spite of the number of studies on… Expand
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Highly Cited
2006
Highly Cited
2006
Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder
BACKGROUND Alterations in the gamma-amino-butyric acid (GABA) neurotransmitter system have been identified in some populations… Expand
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Highly Cited
2003
Highly Cited
2003
Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum
We have previously shown that progesterone (PROG) is synthesized by Schwann cells and promotes myelin formation in the peripheral… Expand
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Highly Cited
2003
Highly Cited
2003
Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats
Previous studies indicate that steroid hormones may be protective for Schwann cells and promote the expression of myelin proteins… Expand
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Highly Cited
2001
Highly Cited
2001
Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation
Allopregnanolone (ALLO), is a brain endogenous neurosteroid that binds with high affinity to γ-aminobutyric acid type A (GABAA… Expand
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Highly Cited
1999
Highly Cited
1999
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… Expand
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Highly Cited
1995
Highly Cited
1995
Reliability of Spike Timing in Neocortical Neurons
screen of the microscope. Between 150 to 300 nerve fibers were analyzed per cross section. 13. C. F. Eldridge, M. Bartlett, R. P… Expand
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Highly Cited
1995
Highly Cited
1995
Gas chromatographic-mass fragmentographic quantitation of 3 alpha- hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats
Coupling high performance liquid chromatography with gas chromatography- mass fragmentography has made it possible to… Expand
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Highly Cited
1993
Highly Cited
1993
Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.
17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) is an enzyme crucial to the regulation of intracellular levels of biologically… Expand
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Highly Cited
1986
Highly Cited
1986
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3… Expand
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