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Modulation of adrenal cell functions by cadmium salts: 3. Sites affected by CdCl2 during stimulated steroid synthesis
In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 mouse adrenal tumor cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway… Expand
Male partner screening before in vitro fertilization: preselecting patients who require intracytoplasmic sperm injection with the sperm penetration assay.
- M. Freeman, A. E. Archibong, J. Mrotek, C. Whitworth, G. Weitzman, G. A. Hill
- Fertility and sterility
- 1 December 2001
OBJECTIVES To determine the diagnostic accuracy of the sperm penetration assay (SPA) and standard semen parameters for subsequent fertilization in in vitro fertilization-embryo transfer (IVF-ET). … Expand
Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons.
- C. Smothers, J. Mrotek, D. Lovinger
- Medicine, Chemistry
- The Journal of pharmacology and experimental…
- 1 December 1997
Effects of chronic ethanol exposure on N-methyl-D-aspartate (NMDA) receptor function were examined in hippocampal neurons. Rat hippocampal neurons grown in culture were chronically exposed to 100 mM… Expand
Production of steroids by in vitro superfusion of endocrine tissue. 3. Corticosterone output from rat adrenals stimulated by adrenocorticotropin or cyclic 3',5'-adenosine monophosphate and the…
Decapsulated rat adrenals were continuously superfused and corticosterone outputs assayed by competitive protein binding or soda fluorescence. During 5 hr superfusions, corticosterone output rate of… Expand
Response of adrenal tumor cells to adrenocorticotropin: site of inhibition by cytochalasin B.
The ability of cytochalasin B to inhibit the steroidogenic response of mouse adrenal tumor cells (Y-1) to adrenocorticotropin (ACTH) was examined with two aims: to consider the specificity of the… Expand
The influence of cytochalasin B on the response of adrenal tumor cells to ACTH and cyclic AMP.
Abstract Cytochalasin B inhibits increase in steroid synthesis by mouse adrenal tumor cells (Y-1), produced either by ACTH or cyclic AMP. Basal levels of steroid synthesis are not decreased and the… Expand
A method for the isolation of lipid droplet fractions from decapsulated rat adrenals
Ultrastructural and cell fractionation studies implicate lipid droplets in the storage of cholesterol and in the secretion of steroids. To evaluate the role of the lipid droplet in steroidogenesis, a… Expand
The actions of various cytochalasins on mouse adrenal tumor cells in relation to trophic stimulation of steroidogenesis.
Abstract Inhibition of the steroidogenic responses to ACTH and dibutyl cyclic AMP in Y-1 cells by four cytochalasins (E, D, B and H2B) was examined to determine whether the capacities of these agents… Expand
Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats.
- J. Clark, A. Sahu, J. Mrotek, S. Kalra
- Biology, Medicine
- The American journal of physiology
- 1 November 1991
Sexual function was examined in spontaneously hypertensive rats (SHR) from 8 to 20 wk of age and compared with normotensive Wistar-Kyoto (WKY) and Long-Evans rats (LE). Blood pressures (evaluated… Expand
Cadmium-induced sexual dysfunction does not involve increased hepatic metabolism of testosterone nor increased circulating levels of corticosterone
- J. T. Clark, B. Jiménez, S. L. Evans, R. Barrow, J. Mrotek
- Biology, Medicine
- Physiology & Behavior
- 1 November 1994
Sexually experienced male rats were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg cadmium chloride. The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function… Expand