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2-hydroxydeoxyadenosine triphosphate

Known as: 2-OH-dATP, 2-hydroxy-2'-deoxyadenosine 5'-triphosphate 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Adenosine Triphosphate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases.
  • H. Kamiya
  • Mutation research
  • 2010
    • Corpus ID: 27881320
The base moieties of DNA precursors in the nucleotide pool are subjected to oxidative damage, and the formation of damaged DNA… Expand
  • table 1
2008
2008
Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.
Aberrant oxidation is a property of many tumor cells. Oxidation of DNA precursors, i.e., deoxynucleotide triphosphates (dNTPs… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
2007
2007
2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract.
The coexistence effects of multiple kinds of oxidized deoxyribonucleotides were examined using an SV40 origin-dependent in vitro… Expand
2007
2007
UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides.
Oxidatively damaged DNA precursors (deoxyribonucleotides) are formed by reactive oxygen species. After the damaged DNA precursors… Expand
  • figure 1
  • figure 2
  • table 1
  • table 3
2004
2004
Induction of transition and transversion mutations during random mutagenesis PCR by the addition of 2-hydroxy-dATP.
A 2-substituted purine nucleotide analog, 2-hydroxy-2'-deoxyadenosine 5'-triphosphate (2-OH-dATP), was added to a PCR mixture, to… Expand
  • table 1
  • table 2
Highly Cited
2003
Highly Cited
2003
An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress*
MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) and 2… Expand
  • figure 1
  • figure 2
  • table I
  • figure 3
  • figure 5
Highly Cited
1998
Highly Cited
1998
Induction of Chromosomal Gene Mutations in Escherichia coli by Direct Incorporation of Oxidatively Damaged Nucleotides
We have developed a new strategy for the evaluation of the mutagenicity of a damaged DNA precursor (deoxyribonucleoside 5… Expand
  • figure 1
  • table I
  • table II
  • table V
  • table III
Highly Cited
1995
Highly Cited
1995
Formation of 2-Hydroxydeoxyadenosine Triphosphate, an Oxidatively Damaged Nucleotide, and Its Incorporation by DNA Polymerases
We found that hydroxylation occurs at the C-2 position of adenine by oxygen radical treatment (Fe-EDTA) of dA, dATP, and single… Expand
1995
1995
2-Hydroxyadenine (isoguanine) as oxidative DNA damage: its formation and mutation inducibility.
In our experiments we found that hydroxylation occurs at the C-2 position of adenine by oxygen radical treatment (Fe(2+)-EDTA) of… Expand
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