2-aminothiazole

 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that selective inhibition of PI3Kα may have… (More)
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Highly Cited
2013
Highly Cited
2013
Phosphatidylinositol-3-kinase α (PI3Kα) is a therapeutic target of high interest in anticancer drug research. On the basis of a… (More)
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2008
2008
An initial SAR study on a series of apamin-displacing 2-aminothiazole K(Ca)2 channel blockers is described. Potent inhibitors… (More)
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2008
2008
Syntheses of 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one 2c-10c are reported in this paper. These compounds 2c-10c… (More)
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Highly Cited
2006
Highly Cited
2006
2-aminothiazole (1) was discovered as a novel Src family kinase inhibitor template through screening of our internal compound… (More)
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2006
2006
A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor… (More)
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2004
2004
2-Aminothiazole derivatives were reported to possess antibacterial [1], antiviral [2], and psychotropic activity [3]. These… (More)
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2004
2004
A series of aminothiazole-derived morphinans, benzomorphans, and morphine were synthesized. Although their affinities were… (More)
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2004
2004
High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl… (More)
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2002
2002
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1- (3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol… (More)
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