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2-amino-3,5-dihydroxyoctadecane

Known as: enigmol 
National Institutes of Health

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Broader (1)

Sphingosine
analogs & derivatives

Papers overview

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2020
2020
Gut bacteria of Varanus salvator possess potential antitumour molecules
Pollution, unhygienic conditions and organic waste are detrimental to human health. On the contrary, animals living in polluted… 
2016
2016
Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.
The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings… 
2015
2015
Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic…
2015
2015
Role of Macroautophagy in Anti‐Cancer Effects of the Novel Sphingolipid, Enigmol
Enigmol ([2S,3S,5S]‐2‐amino‐3,5‐dihydroxyoctadecane) is a novel sphingolipid analog that inhibits tumor growth in preclinical… 
2013
2013
330 FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS IN VIVOPROSTATE CANCER EFFICACY
2011
2011
Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer.
Enigmol is a synthetic, orally active 1-deoxysphingoid base analogue that has demonstrated promising activity against prostate… 
2010
2010
An efficient asymmetric synthesis of Enigmols (1-deoxy-5- hydroxysphingoid bases), an important class of bioactive lipid modulators
An enantioselective synthesis of the four 2S-diastereomers of enigmol (2-amino-octadecane-3,5diols) from L-alanine is reported… 
2008
2008
ENIGMOL (2-AMINO-3,5-DIHYDROXYOCTADECANE [2S, 3S, 5S]) IS A NOVEL SPHINGOLIPID ANALOG THAT SHOWS A PROMISING EFFECT IN THE TREATMENT OF PROSTATE CANCER
2007
2007
Regulation of aberrant cell processes with non‐toxic doses of Sphingosine and Enigmol: initial investigation of the chemopreventive potential of natural and synthetic sphingoid bases in a cell model…
We have recently isolated mouse ovarian surface epithelium (MOSE) that spontaneously undergo transformation in vitro and… 
2006
2006
Effects of sphingosine and Enigmol on mouse ovarian surface epithelial cells representing early, intermediate and late stages of ovarian cancer
Proc Amer Assoc Cancer Res, Volume 47, 2006 3177 Studies to identify early markers of ovarian cancer to support the… 
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