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2'-fluoro-2'-deoxyadenosine

Known as: 2'-deoxy-2'-fluoroadenosine, 5'-FDA 
National Institutes of Health

Related topics

Related topics

2 relations
2'-deoxy-2-fluoroadenosine

Broader (1)

Deoxyadenosines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides
Thermostable nucleoside phosphorylases are attractive biocatalysts for the synthesis of modified nucleosides. Hence we report on… Expand
2005
2005
Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY.
The oxidation product of 2'-deoxyguanosine, 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG), produces G:C to T:A transversion mutations… Expand
2004
2004
A residue in MutY important for catalysis identified by photocross-linking and mass spectrometry.
MutY is an adenine glycosylase in the base excision repair (BER) superfamily that is involved in the repair of 7,8-dihydro-8-oxo… Expand
Highly Cited
2003
Highly Cited
2003
Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state…
The oxidized guanine lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG) is highly mutagenic, resulting in G:C to T:A transversion… Expand
1995
1995
Potent inhibitors of human inosine monophosphate dehydrogenase type II. Fluorine-substituted analogues of thiazole-4-carboxamide adenine dinucleotide.
Three analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) (1-3) containing a fluorine atom at the C2' of the adenine… Expand
Highly Cited
1993
Highly Cited
1993
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.
"Uniformly" modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-deoxy-2'-fluoroadenosine, -guanosine… Expand
Highly Cited
1991
Highly Cited
1991
Study of a hammerhead ribozyme containing 2'-modified adenosine residues.
The improved synthesis of 2'-fluoro-2'-deoxyadenosine (2'-FA) starting from adenosine is described. This compound was converted… Expand
1984
1984
Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties.
The deoxyribooctanucleotide d(G-G-A-A-T-T-C-C), containing the recognition sequence for EcoRI, d(G-A-A-T-T-C), and analogs… Expand
1983
1983
Multinuclear magnetic resonance studies of monomers and diemrs containing 2′‐fluoro‐2′‐deoxyadenosine
A series of 2′‐fluorinated adenosine compounds, dAfl, dAflp, pdAfl, dAfl‐A, A‐dAfl, and dAfl‐dAfl, have been investigated by nmr… Expand
1981
1981
Synthesis and characterization of the dinucleoside monophosphates containing 2'-fluoro-2'-deoxyadenosine.
Three dinucleoside monophosphates containing 2'-fluor-2'-deoxyadenosine (dAfl), dAfl-dAfl, dAfl-A, and A-dAfl, were synthesized… Expand
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