Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine.

@article{Zatorski1993SynthesisOT,
  title={Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine.},
  author={A. Zatorski and P. Lipka and N. Mollova and K. Schram and B. Goldstein and K. Watanabe and K. Pankiewicz},
  journal={Carbohydrate research},
  year={1993},
  volume={249 1},
  pages={
          95-108
        }
}
  • A. Zatorski, P. Lipka, +4 authors K. Pankiewicz
  • Published 1993
  • Chemistry, Medicine
  • Carbohydrate research
  • Synthesis of an analogue 3 of thiazole-4-carboxamide adenine-dinucleotide (TAD) in which the beta-oxygen atom of the pyrophosphate bridge is replaced by a difluoromethylene group has been achieved. Likewise, 2'-deoxy-2'-fluoroadenosine containing analogues of TAD (4) and its difluoromethylenediphosphonate congener (5) have been synthesized. Adenosine 5'-difluoromethylenediphosphonate (8) was prepared from 5'-O-tosyladenosine (6) and tris(tetra-n-butylammonium)difluoromethylenediphosphonate (7… CONTINUE READING
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    References

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