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17-hydroxywortmannin

 
National Institutes of Health

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Broader (1)

Androstadienes

Papers overview

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2008
2008
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently up-regulated in human cancer and is a promising target for… Expand
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2006
2006
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway… Expand
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2005
2005
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Deregulated phosphatidylinositol 3-kinase (PI3K) signaling pathway is widely implicated in tumor growth and resistance to… Expand
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Highly Cited
1994
Highly Cited
1994
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
Wortmannin (WT) and its derivative 17-hydroxywortmannin (HWT) inhibit at nanomolar concentrations superoxide formation and… Expand
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1993
1993
Serine/threonine kinases in signal transduction in response to thrombin in human platelets. Use of 17-hydroxywortmannin to discriminate signals.
Although the importance of protein kinases in platelet activation, particularly protein kinase C (PKC), is well established there… Expand
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1990
1990
Corresponding oscillations in neutrophil shape and filamentous actin content.
Human neutrophils pretreated with 17-hydroxywortmannin responded to the chemotactic agonist formyl-Met-Leu-Phe with a transient… Expand
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1989
1989
Respiratory burst oscillations in human neutrophils and their correlation with fluctuations in apparent cell shape.
Neutrophils pretreated with phorbol 12-myristate 13-acetate (1-10 nM) and stimulated with low concentrations of chemotactic… Expand
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Highly Cited
1988
Highly Cited
1988
Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist.
The rise in cytosolic free Ca2+, shape change, superoxide formation, and granule exocytosis induced in human neutrophils by N… Expand
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1988
1988
Two transduction sequences are necessary for neutrophil activation by receptor agonists.
The effects of 17-hydroxywortmannin (HWT), a powerful inhibitor of the respiratory burst associated with phagocytosis (Baggiolini… Expand
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1987
1987
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
Human neutrophils treated with the secretion inhibitor 17-hydroxywortmannin were stimulated with fMLP, C5a, PAF or LTB4, and the… Expand
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