17-hydroxywortmannin

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2010
0119872010

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2010
2010
Hyperactivation of the PI3K/AKT/mTOR signaling pathway is common in cancer, and PI3K and mTOR act synergistically in promoting… (More)
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2008
2008
The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently up-regulated in human cancer and is a promising target for… (More)
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2006
2006
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway… (More)
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2005
2005
Deregulated phosphatidylinositol 3-kinase (PI3K) signaling pathway is widely implicated in tumor growth and resistance to… (More)
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Highly Cited
1994
Highly Cited
1994
Wortmannin (WT) and its derivative 17-hydroxywortmannin (HWT) inhibit at nanomolar concentrations superoxide formation and… (More)
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1993
1993
Although the importance of protein kinases in platelet activation, particularly protein kinase C (PKC), is well established there… (More)
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1991
1991
Protein kinases are involved in signal transduction in human blood platelets. A number of renaturable protein kinases have… (More)
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1990
1990
Human neutrophils pretreated with 17-hydroxywortmannin responded to the chemotactic agonist formyl-Met-Leu-Phe with a transient… (More)
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Highly Cited
1988
Highly Cited
1988
The rise in cytosolic free Ca2+, shape change, superoxide formation, and granule exocytosis induced in human neutrophils by N… (More)
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1988
1988
The effects of 17-hydroxywortmannin (HWT), a powerful inhibitor of the respiratory burst associated with phagocytosis (Baggiolini… (More)
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