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17-hydroxywortmannin

National Institutes of Health

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Broader (1)

Androstadienes

Papers overview

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2008
2008
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently up-regulated in human cancer and is a promising target for… 
2006
2006
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway… 
2006
2006
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.
Highly Cited
2005
Highly Cited
2005
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Deregulated phosphatidylinositol 3-kinase (PI3K) signaling pathway is widely implicated in tumor growth and resistance to… 
Highly Cited
1994
Highly Cited
1994
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
Wortmannin (WT) and its derivative 17-hydroxywortmannin (HWT) inhibit at nanomolar concentrations superoxide formation and… 
1992
1992
Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst.
A comparative study of real-time kinetics of respiratory burst, monitored by H2O2-dependent chemiluminescence, and phospholipase… 
Highly Cited
1990
Highly Cited
1990
Corresponding oscillations in neutrophil shape and filamentous actin content.
Highly Cited
1989
Highly Cited
1989
Respiratory burst oscillations in human neutrophils and their correlation with fluctuations in apparent cell shape.
Highly Cited
1988
Highly Cited
1988
Two transduction sequences are necessary for neutrophil activation by receptor agonists.
1987
1987
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
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