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17-hydroxywortmannin

National Institutes of Health

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Androstadienes

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2017
2017
Patent Number : 5 , 504 , 103 45 Date of Patent : Apr . 2 , 1996 54 ) INHIBITION OF PHOSPHATIDYLINOSITOL 3-KNASE WITH 17 B-HYDROXYWORTMANNIN AND ANALOGS THEREOF
Yano, Hiroshi, et al., J. Biol. Chem, 268(34):25846-25856 (1993) Inhibition of histamine secretion by wortmannin through the… 
2010
2010
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.
Hyperactivation of the PI3K/AKT/mTOR signaling pathway is common in cancer, and PI3K and mTOR act synergistically in promoting… 
2008
2008
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently up-regulated in human cancer and is a promising target for… 
2006
2006
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway… 
2006
2006
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.
2006
2006
165 POSTER Furan ring-opened 17-hydroxywortmannin analogs as phcsphoinositide 3-kinase inhibitors active in human tumor xenograft models
1993
1993
Serine/threonine kinases in signal transduction in response to thrombin in human platelets. Use of 17-hydroxywortmannin to discriminate signals.
Although the importance of protein kinases in platelet activation, particularly protein kinase C (PKC), is well established there… 
1992
1992
Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst.
A comparative study of real-time kinetics of respiratory burst, monitored by H2O2-dependent chemiluminescence, and phospholipase… 
1991
1991
Effects of 17‐hydroxywortmannin on serine/threonine‐protein kinases in human blood platelets
1987
1987
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
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