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17-hydroxywortmannin

 
National Institutes of Health

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Broader (1)

Androstadienes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently up-regulated in human cancer and is a promising target for… Expand
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2006
2006
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway… Expand
Highly Cited
2005
Highly Cited
2005
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Deregulated phosphatidylinositol 3-kinase (PI3K) signaling pathway is widely implicated in tumor growth and resistance to… Expand
Highly Cited
1994
Highly Cited
1994
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
Wortmannin (WT) and its derivative 17-hydroxywortmannin (HWT) inhibit at nanomolar concentrations superoxide formation and… Expand
1992
1992
Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst.
A comparative study of real-time kinetics of respiratory burst, monitored by H2O2-dependent chemiluminescence, and phospholipase… Expand
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Highly Cited
1990
Highly Cited
1990
Corresponding oscillations in neutrophil shape and filamentous actin content.
Human neutrophils pretreated with 17-hydroxywortmannin responded to the chemotactic agonist formyl-Met-Leu-Phe with a transient… Expand
Highly Cited
1989
Highly Cited
1989
Respiratory burst oscillations in human neutrophils and their correlation with fluctuations in apparent cell shape.
Neutrophils pretreated with phorbol 12-myristate 13-acetate (1-10 nM) and stimulated with low concentrations of chemotactic… Expand
Highly Cited
1988
Highly Cited
1988
Mechanism of neutrophil activation by NAF, a novel monocyte‐derived peptide agonist
The rise in cytosolic free Ca2+, shape change, superoxide formation, and granule exocytosis induced in human neutrophils by N… Expand
Highly Cited
1988
Highly Cited
1988
Two transduction sequences are necessary for neutrophil activation by receptor agonists.
The effects of 17-hydroxywortmannin (HWT), a powerful inhibitor of the respiratory burst associated with phagocytosis (Baggiolini… Expand
1987
1987
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
Human neutrophils treated with the secretion inhibitor 17-hydroxywortmannin were stimulated with fMLP, C5a, PAF or LTB4, and the… Expand
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