17-hydroxypregnenolone

Known as: 17-OH-Pregnenolone, Hydroxypregnenolone, 17a-Pregnenolone 
An endogenous steroid hormone synthesized by the hydroxylation of pregnenolone, which can act either as a neuroactive steroid or as a prohormone for… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CONTEXT Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant… (More)
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2010
2010
We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a… (More)
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2008
2008
Melatonin regulates diurnal changes in locomotor activity in vertebrates, but the molecular mechanism for this neurohormonal… (More)
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Review
2005
Review
2005
CYP17 is a steroidogenic enzyme located in the zona fasciculata and zona reticularis of the adrenal cortex and gonad tissues and… (More)
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2004
2004
It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called… (More)
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2003
2003
Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors… (More)
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2001
2001
Steroids synthesized de novo from cholesterol in the brain are generally called neurosteroids. We have recently demonstrated… (More)
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Highly Cited
1999
Highly Cited
1999
P450c17 (17alpha-hydroxylase/17,20-lyase) catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of… (More)
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1992
1992
Neonatal plasma contains interferents that increase the apparent 17 alpha-hydroxyprogesterone (17-OHP) content measured by direct… (More)
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Highly Cited
1986
Highly Cited
1986
Cortisol production requires the activity of only 17 alpha-hydroxylase, whereas the formation of sex steroids requires both 17… (More)
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