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17-hydroxypregnenolone

Known as: 17-OH-Pregnenolone, Hydroxypregnenolone, 17a-Pregnenolone 
An endogenous steroid hormone synthesized by the hydroxylation of pregnenolone, which can act either as a neuroactive steroid or as a prohormone for… 
National Institutes of Health

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12 relations

Narrower (4)

16 alpha-hydroxypregnenolone 7-(O-carboxymethyl)oxime17-hydroxypregnenolone sulfate19-hydroxypregnenolone 3-acetate21-hydroxypregnenolone
17-Hydroxypregnenolone:MRat:24H:Urine:QnIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Liquid chromatography-tandem mass spectrometry applications in endocrinology.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been recognized as a primary methodology for the accurate analysis… 
Highly Cited
2003
Highly Cited
2003
CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding*
Cytochrome P450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors… 
Highly Cited
1993
Highly Cited
1993
Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20…
Highly Cited
1991
Highly Cited
1991
Influence of age and endocrine factors on the volume of benign prostatic hyperplasia.
Highly Cited
1990
Highly Cited
1990
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism
Highly Cited
1986
Highly Cited
1986
Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells.
Cortisol production requires the activity of only 17 alpha-hydroxylase, whereas the formation of sex steroids requires both 17… 
Highly Cited
1985
Highly Cited
1985
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia.
A six-month-old 46,XY infant with a female phenotype and ambiguous genitalia was evaluated for male pseudohermaphroditism. The… 
Highly Cited
1981
Highly Cited
1981
Testicular microsomal cytochrome P-450 for C21 steroid side chain cleavage. Spectral and binding studies.
Highly Cited
1976
Highly Cited
1976
A simple method for the assay of eight steroids in small volumes of plasma
Highly Cited
1969
Highly Cited
1969
Steroid metabolism in the human foeto-placental unit.
The concept of a fetoplacental unit as a steroid-synthesizing unit was elaborated by perfusing the previable fetus and placenta… 
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