Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
- L. Kriegsfeld, Dan Feng Mei, R. Silver
- BiologyProceedings of the National Academy of Sciences…
- 7 February 2006
The distribution of GnIH efferents to neural sites regulating reproductive behavior and neuroendocrine secretions, expression of steroid receptors in GnIh-ir nuclei, and GnI H inhibition of luteinizing hormone secretion indicate the discovery of a system regulating the mammalian reproductive axis.
A novel avian hypothalamic peptide inhibiting gonadotropin release.
- K. Tsutsui, E. Saigoh, P. Sharp
- BiologyBiochemical and Biophysical Research…
- 28 August 2000
It is shown, in a bird, that the hypothalamus also contains a novel peptide which inhibits gonadotropin release, the first hypothalamic peptide inhibiting gonadotropic hormone reported in a vertebrate.
Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat
- Marlie A. Johnson, K. Tsutsui, G. Fraley
- BiologyHormones and Behavior
- 31 January 2007
Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.
- Yeo Reum Lee, K. Tsunekawa, K. Tsutsui
- BiologyEndocrinology
- 22 January 2009
This study is the first to identify a mature form of KiSS-2 product in the brain of any vertebrate, and shed new light on the molecular evolution of the kisspeptin-GPR54 system in vertebrates.
Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.
- I. Clarke, I. P. Sari, G. Bentley
- Biology, MedicineEndocrinology
- 10 July 2008
Data indicate that RFRP-3 is a specific and potent mammalian gonadotropin-inhibiting hormone, and that it acts upon pituitary gonadotropic gland function to reduce GnRH-stimulated gonADotropin secretion.
Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone.
- T. Ubuka, Kazuhiko Inoue, K. Tsutsui
- BiologyEndocrinology
- 2012
The results suggest that GnIH peptides fine tune LH levels via its receptor expressed in GnRH-ir neurons in an opposing fashion across the seasons in Siberian hamsters.
Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6
- M. Doi, Yukari Takahashi, H. Okamura
- BiologyNature Network Boston
- 2010
Type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6) is identified as a new hypertension risk factor in mice and placed in a pivotal position through which circadian clock malfunction is coupled to the development of hypertension.
Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain.
- T. Ubuka, G. Bentley, K. Ukena, J. Wingfield, K. Tsutsui
- BiologyProceedings of the National Academy of Sciences…
- 22 February 2005
It is shown that melatonin originating from the pineal gland and eyes induces GnIH expression in the quail brain, the first demonstration, to the authors' knowledge, of a direct action of melatonin on neuropeptide induction in any vertebrate class.
Identification of Human GnIH Homologs, RFRP-1 and RFRP-3, and the Cognate Receptor, GPR147 in the Human Hypothalamic Pituitary Axis
- T. Ubuka, K. Morgan, G. Bentley
- BiologyPLoS ONE
- 22 December 2009
The identification of two forms of GnIH (R FRP-1 and RFRP-3) in the human hypothalamus which targets human GnRH neurons and gonadotropes and potently inhibit gonadotropic hormone in sheep models provides a new paradigm for the regulation of hypothalamic-pituitary-gonadal axis in man and a novel means for manipulating reproductive functions.
Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides
- J. D. Rego, J. Seong, H. Vaudry
- Biology, PsychologyFrontiers in neuroendocrinology (Print)
- 1 August 2009
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