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14-methoxymetopon

Known as: Morphinan-6-one, 4,5-epoxy-3-hydroxy-14-methoxy-5,17-dimethyl-, (5alpha)- 
 
National Institutes of Health

Papers overview

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2010
2010
Opioids are the most effective analgesics for pain management, and efficient pain control is a therapeutic priority. Herein, we… Expand
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2007
2007
RationaleIncreased opioidergic activity is thought to increase the propensity to consume ethanol. However, the dose monotonicity… Expand
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2006
2006
Previous studies showed that opioid drugs-oxycodone-6-oxime and 14-methoxy-5-methyl-dihydromorphinone (14-methoxymetopon… Expand
2003
2003
14-Methoxymetopon is a potent opioid analgesic. When given systemically, it is approximately 500-fold more active than morphine… Expand
2003
2003
The highly potent µ‐opioid receptor agonist 14‐methoxymetopon (4,5α‐epoxy‐3‐hydroxy‐14β‐methoxy‐5β,17‐dimethylmorphinan‐6‐one… Expand
2003
2003
The synthesis and the biological and pharmacological evaluation of several 14-phenylpropoxy analogues of 14-methoxymetopon are… Expand
2002
2002
We have studied the effects of 14-methoxymetopon (HS 198), a potent opioid agonist, on the responses to the tail electric… Expand
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2000
2000
Opioids of the &mgr;-receptor type depress respiration and induce addiction. At 10-min intervals 14-methoxymetopon (HS-198… Expand
2000
2000
In search of a truly high-efficacy (i.e., tau > 100) mu opioid analgesic, we determined the efficacy (tau) and apparent in vivo… Expand
1993
1993
The newly synthesized 14-alkoxymetopon derivatives, 14-methoxymetopon, 14-ethoxymetopon, 14-methoxy-5-methyl-morphinone, exhibit… Expand