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10-deoxymethynolide

National Institutes of Health

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Macrolides

Papers overview

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2015
2015
Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.
The gram-positive prokaryotes of the Streptomyces genus are prolific producers of secondary metabolites including a plethora of… 
2012
2012
Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs.
A strategy for regiochemical reversal of reductive macrocyclizations of aldehydes and terminal alkynes has been developed. Using… 
2008
2008
Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3.
Two sugar biosynthetic cassette plasmids were used to direct the biosynthesis of a deoxyaminosugar. The pOTBP1 plasmid containing… 
2004
2004
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
The heterologous expression of tylM3 and mydC, two homologous genes of previously unknown function, along with genes encoding… 
2004
2004
Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.
EryCIII converts alpha-mycarosyl erythronolide B into erythromycin D using TDP-d-desosamine as the glycosyl donor. We report the… 
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