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1-methyluric acid

 
National Institutes of Health

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1-methylurate

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Uric Acid
analogs & derivatives

Papers overview

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Highly Cited
2007
Highly Cited
2007
In vitro antioxidant activity of coffee compounds and their metabolites.
In this paper we report the antioxidant activity of different compounds which are present in coffee or are produced as a result… Expand
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2002
2002
Severe 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) intoxication: Insights into the measurement of hepatic cytochrome P450 1A2 induction *
The correct in vivo quantification of aryl hydrocarbon receptor‐mediated induction of cytochrome P450 1A2 (CYP1A2) in humans is a… Expand
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2001
2001
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of…
An automated reversed-phase high-performance liquid chromatographic (RP-HPLC) method, using a linear gradient elution, is… Expand
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Highly Cited
2001
Highly Cited
2001
Fluvoxamine‐theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2
Several reports indicate that fluvoxamine decreases the clearance of cytochrome P4501A2 (CYP1A2) substrates. This study compared… Expand
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Highly Cited
2000
Highly Cited
2000
Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation.
  • C. Lee
  • Clinica chimica acta; international journal of…
  • 2000
    • Corpus ID: 22870443
Although caffeine has been suggested as an antioxidant at millimolar concentrations, little information is available about the… Expand
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1996
1996
Validation of urine caffeine metabolite ratios with use of stable isotope‐labeled caffeine clearance
A number of caffeine metabolite ratios have been proposed to measure CYP1A2 activity in vivo. The data to validate these ratios… Expand
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Highly Cited
1996
Highly Cited
1996
Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans.
Caffeine metabolism via the 3-demethylation pathway is sequentially catalyzed by cytochrome P4501A2 (CYP1A2), xanthine oxidase… Expand
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Highly Cited
1992
Highly Cited
1992
Racial and gender differences in N‐acetyltransferase, xanthine oxidase, and CYP1A2 * activities
The urinary molar concentration ratios of several caffeine metabolites are indicators of specific drug metabolizing enzyme… Expand
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Highly Cited
1983
Highly Cited
1983
Secondary metabolism of theophylline biotransformation products in man--route of formation of 1-methyluric acid.
The route of formation of 1-methyluric acid (1MU) from theophylline has been investigated by i.v. administration of 1… Expand
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Highly Cited
1982
Highly Cited
1982
Nonlinear theophylline elimination
Elimination kinetics of theophylline and its major metabolites were investigated in 14 healthy adults in single‐dose studies and… Expand
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