1,2,4,5-Tetraoxanes
National Institutes of Health
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Although antischistosomal properties of peroxides were studied in recent years, systematic structure-activity relationships have…
The discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy…
Dispiro-1,2,4,5-tetraoxanes and 1,2,4-trioxolanes represent attractive classes of synthetic antimalarial peroxides due to their…
Trioxane based compounds such as artemisinin and its synthetic and semi-synthetic analogues constitute promising class of…
Re(2)O(7) is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes…
Unsymmetrical dispiro- and spirotetraoxanes have been designed and synthesized via acid-catalyzed cyclocondensation of bis…
Mixed 1,2,4,5-tetraoxanes possessing simple spirocycloalkane and spirocholic acid-derived substituents were prepared and shown to…
Methods for formation of 1,2,4,5-tetraoxanes are summarized and antimalarial activities of 1,2,4,5-tetraoxanes are discussed.
Cholic acid-derived 1,2,4,5-tetraoxanes were synthesized in order to explore the influence of steroid carrier on its antimalarial…