Vitamin D und Parathormon: Ein Weg zur Bestimmung methodenabhängiger unterer Grenzwerte für Vitamin D / Vitamin D and parathyroid hormone: a tool to determine assay-specific cutoff values for vitamin D

@inproceedings{Thierfelder2008VitaminDU,
  title={Vitamin D und Parathormon: Ein Weg zur Bestimmung methodenabh{\"a}ngiger unterer Grenzwerte f{\"u}r Vitamin D / Vitamin D and parathyroid hormone: a tool to determine assay-specific cutoff values for vitamin D},
  author={Wulf Thierfelder and Heinz Juergen Roth and Detlef Laussmann and Ludger Pientka and Jochen Schumacher and J{\"o}rg B Schulz and Christa Scheidt-Nave},
  year={2008},
  url={https://api.semanticscholar.org/CorpusID:71995782}
}
Vitamin D status is best assessed by measuring serum 25-hydroxyvitamin [25(OH)D], which concentrations far above the deficiency threshold for skeletal health may be suboptimal with respect to long-term health consequences.
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Alleskönner Vitamin D?

The study results on prevention and therapy of various diseases with vitamin-D show inconsistent results and a critical analysis of the currently established therapeutic reference range, which defines a vitamin D deficiency is reviewed.

Association of circulating 25-hydroxyvitamin D with mental well-being in a population-based, nationally representative sample of German adolescents

These findings linking 25(OH)D to better well-being in a nationally representative sample of German children and adolescents suggest beneficial effects of vitamin D on mental health, however, recommendations for vitamin supplementation in healthy children andolescents are not warranted.

Quality of life and mental health in adolescent users of oral contraceptives. Results from the nationwide, representative German Health Interview and Examination Survey for Children and Adolescents (KiGGS)

In a large, representative sample of German adolescents, exposure to exogenous contraceptive hormones was associated with higher arterial blood pressure and serum 25(OH)D concentration, whereas hormonal contraception was not linked to health-related quality of life or mental well-being.

Assessing health in children: national surveys and the role of the laboratory.

Vitamin D Deficiency and Fertility: An Overview

29 References

Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography–tandem mass spectrometry as a reference

Standardization of methods for the quantification of 25(OH)D on a human-based sample panel by means of LC-MS/MS would help to reduce the inter-method variability with respect to accuracy existing in 25( OH)D measurement considerably.

Measurement of 25-hydroxyvitamin D by the Nichols ADVANTAGE, DiaSorin LIAISON, DiaSorin RIA, and liquid chromatography-tandem mass spectrometry.

Assessment of the monohydroxy form of vitamin D is important for identifying insufficient endogenous synthesis disorders that impair gastrointestinal absorption and to identify renal or hepatic abnormalities.

How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme.

The international Vitamin D Quality Assessment Scheme (DEQAS) has been monitoring the performance of 25OHD assays since 1989 and now has >100 registered participants in 18 countries and provides a unique opportunity to assess the accuracy and specificity of25OHD methods as well as the analytical performance of a large number of their users.

Divergence in classification of 25-hydroxyvitamin D status with respect to immunoassays.

This study studied 199 people who were residents of Paris and its suburbs and who suffered primary hyperparathyroidism, secondary HPT with hemodialysis or obesity, mild asthenia, depression, and/or osteopenia/osteoporosis and evaluated the 25-OHD LIAISON® chemiluminescent immunoassay (CLIA) proposed by the same manufacturer as an alternative assay.

An International Comparison of Serum 25-Hydroxyvitamin D Measurements

Results show that 25(OH)D values from different laboratories can not be assumed to be comparable unless a careful cross-calibration has been performed, and interlaboratory variation may hamper comparison between results from different populations.

Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females

It is found that the widely used cutoff for vitamin D deficiency is associated with increasing PTH levels and is below the inflection point for a change in the slope of the regression line.

Measurement of vitamin D status: background, clinical use, and methodologies.

It has been shown that the vitamin D requirements have been underestimated and that vitamin D2 is much less potent than vitamin D3, and future studies will determine the amount ofitamin D3 necessary for optimal health and well-being.

Validation of the first automated chemiluminescence protein-binding assay for the detection of 25-hydroxycalciferol.

The validated CLPBA is a very promising alternative to established commercially available 25(OH)D measurements and will, with its use on a fully automated platform, simplify the reliable quantification of 25-hydroxycalciferol significantly.

Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women.

The data suggest that aging women should maintain 25(OH)D concentrations >40 nmol/L (which is the lower limit of the normal range for healthy young subjects) for optimal bone health.

Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.

As long as vitamin D status is ensured, calcium intake levels of more than 800 mg/d may be unnecessary for maintaining calcium metabolism, and Vitamin D supplements are necessary for adequateitamin D status in northern climates.