Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.

  title={Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.},
  author={Melanie M. Barra and David M. Richards and Jenny Hansson and Ann-Cathrin Hofer and Michael Delacher and Jan Hettinger and Jeroen Krijgsveld and Markus Feuerer},
  journal={Journal of immunology},
  volume={195 7},
Regulatory T cells (Tregs) differentiate in the thymus, but the mechanisms that control this process are not fully understood. We generated a comprehensive quantitative and differential proteome of murine Tregs and conventional T cells. We identified 5225 proteins, 164 of which were differentially expressed in Tregs. Together with the comparative analysis of proteome and gene expression data, we identified TCF7 as a promising candidate. Genetic elimination of transcription factor 7 (TCF7) led… CONTINUE READING

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Selection of regulatory T cells in the thymus

Nature Reviews Immunology • 2012
View 3 Excerpts
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TCF - 1 and LEF1 act upstream of ThPOK to promote the CD 4 ( + ) T cell fate and interact with Runx 3 to silence Cd 4 in CD 8 ( + ) T cells

V. Ioannidis, F. Beermann, H. Clevers
Nat . Immunol . • 2014

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