Total Synthesis of Flavin-adenine-dinucleotide

@article{Christie1952TotalSO,
  title={Total Synthesis of Flavin-adenine-dinucleotide},
  author={Stuart M. H. Christie and George Wallace Kenner and Alexander Robertus Todd},
  journal={Nature},
  year={1952},
  volume={170},
  pages={924-924},
  url={https://api.semanticscholar.org/CorpusID:410526}
}
Flavin-adenine-dinucleotide is the coenzyme of a number of flavoprotein enzymes functioning as oxidation-reduction catalysts in biological systems, and indeed the members of the group are usually described loosely as nucleotide coenzymes.
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12 Citations

12 Citations

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes.

The state of the art on a key area of research in flavin enzymology: the molecular basis for the activation of O2 by flavin-dependent oxidases and monooxygenases is summarized.

Anti-Diabetic Potential of Anti-Oxidant Compounds "Riboflavin, Flavin Mononucleotide and Flavin Adenine Dinucleotide" with High Therapeutic Potency through Inhibition of α-Amylase and α-Glucosidase Enzymes at Sub-Micromolar Concentrations

These antioxidant inhibitors may be potential anti-diabetic drugs, not only to reduce glycemic index, but also to limit the activity of the major reactive oxygen species (ROS) producing pathways.

Advances in the chemistry of natural flavins

The review discusses advances in the chemistry of isoalloxazines in the last 10 years, including 1978, in the field of the detection of new derivatives of flavin (7,8-dimethylisoalloxazine) and…

Flavin nucleotides and flavoproteins

Diese Substanzen können durch spezifische mikrobiologische und enzymatische Untersuchungen, Absorptions- and Fluoreszenzspektra und Papierchromatographie identifiziert und voneinander unterschieden werden.

Looking Back: A Short History of the Discovery of Enzymes and How They Became Powerful Chemical Tools

This historical review highlights the developments across several fields that were necessary to create the modern field of biocatalysis, with enzyme engineering and directed evolution at its core, and exemplifies the modular, incremental, and highly unpredictable nature of scientific discovery.

Studien auf dem Gebiete der Nucleotid‐Synthese Nobel‐Vortrag am 11. Dezember 1957

Es wird ein Uberblick uber eigene Arbeiten auf dem Gebiet der Nucleoside, Nucleotide und Nuclein-sauren, insbesondere uber Darstellung und Eigenschaften organischer Phosphate, Pyrophosphate und…

Functional Divergence of Photolyase and Cryptochrome-DASH: The Role of Loop Dynamics

Synthesis in the study of nucleotides; basic work on phosphorylation opens the way to an attack on nucleic acids and nucleotide coenzymes.

Lord Todd 1907-1997.

CHAPTER III – RIBOFLAVINE

8 References

Reversible enzymatic synthesis of flavin-adenine dinucleotide.

Prosthetic Group of Glucose Oxidase (Notatin)

The enzyme discovered by Müller, which catalyses the oxidation of glucose to gluconic acid by means of molecular oxygen, must be a flavoprotein, as the marked antibacterial property which it exhibits in presence of glucose and air is due to hydrogen peroxide produced by the reduction of atmospheric oxygen.

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705. Nucleotides. Part XVII. N-Chloroamides as reagents for the chlorination of diesters of phosphorous acid. A new synthesis of uridine-5′ pyrophosphate

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