• Corpus ID: 25687376

Studies of transplantation immunology with major histocompatibility complex knockout mice.

@article{Chitilian1997StudiesOT,
  title={Studies of transplantation immunology with major histocompatibility complex knockout mice.},
  author={Hovig V. Chitilian and Hugh Auchincloss},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={1997},
  volume={16 2},
  pages={
          153-9
        },
  url={https://api.semanticscholar.org/CorpusID:25687376}
}
Xenotransplantation experiments involving these animals have revealed that donor MHC deficiency offers no protection to the graft, suggesting that strategies to eliminate MHC antigen expression will not be successful in generating "universal donors."
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17 Citations

Instillation of allogeneic lung antigen-presenting cells deficient in expression of major histocompatibility complex class I or II antigens have differential effects on local cellular and humoral immunity and on pathology in recipient murine lungs.

The data show that donor MHC class I and II molecules have differential effects in the stimulation of local alloimmune responses, including IFN-gamma and IgG2a synthesis locally, though less than that induced by wild-type cells.

The Role of the Class II Transactivator (CIITA) in MHC Class I and II Regulation and Graft Rejection in Kidney

CIITA‐deficient kidneys have no basal and induced class II expression but display intense induction of class I expression, and evoke typical rejection lesions, although some indices of infiltration are reduced at day 21.

Xenografts of MHC-Deficient Mouse Embryonic Mesencephalon Improve Behavioral Recovery in Hemiparkinsonian Rats

Results show that MHC class II-deficient xenografts survive transplantation for at least 6 weeks in the absence of immunosup-pression, reduce rotational asymmetry, and provoke lesser immune reaction than wt grafts.

Human HLA specific antibodies crossreact with swine leucocyte antigens

There is cross reactivity between IgG anti-HLA and pig lymphocytes and the results show that the majority of anti-pig reactivity was abrogated.

Blockade of indirect recognition mediated by CD4+ T cells leads to prolonged cardiac xenograft survival

It is demonstrated that indirect recognition mediated by CD4+ T cells plays a critical role in the rejection of cardiac grafts in the rat‐to‐mouse xenogeneic model.

Redefining peripheral tolerance in the BALB/c to CBA mouse cardiac allograft model: vascular and cytokine analysis after transient CD4 T cell depletion.

Well-preserved hearts from tolerant mice had lower levels of macrophage and T cell infiltration and decreased transcription of interferon-gamma, interleukin (IL)-2, IL-10, and inducible nitric oxide synthase, compared with rejecting mice.

Modification of Fibroblast γ-Interferon Responses by Extracellular Matrix

It is proposed that interaction of fibroblasts with the fibroblast-derived extracellular matrix is an important modulator of γ-interferon responsiveness and that this interaction may play a role in the low immunogenicity of allogeneic fibro Blasts grown on scaffolds.

Idarubicin-145-2C11-F(ab')2 promotes peripheral tolerance and reduces chronic vascular disease in mouse cardiac allografts.

Murine mentors: transgenic and knockout models of surgical disease.

The goals of this review are to outline the techniques of creating transgenic and knockout mice, and to demonstrate their use in elucidation of the molecular mechanisms underlying common surgical diseases.

Further Analysis of the T‐Cell Subsets and Pathways of Murine Cardiac Allograft Rejection

The present study examined the role of CD4+ and CD8+ T cells in cardiac allograft rejection when either the direct or indirect pathway was eliminated for the CD4+ portion of the response. To study…