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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrinExpand
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Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse
The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive TExpand
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The immunological synapse: integrins take the stage
Summary: Adhesive interactions play important roles in coordinating T‐cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell‐cell junction.Expand
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WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.
WIP stabilizes actin filaments and is important for filopodium formation. To define the role of WIP in immunity, we generated WIP-deficient mice. WIP(minus sign/minus sign) mice have normalExpand
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Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecules (ICAMs) facilitates T cell antigen receptor (TCR)-mediated killing. To dissect TCR and LFA-1Expand
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Cytotoxic T lymphocytes form an antigen-independent ring junction.
Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cellExpand
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Lateral membrane waves constitute a universal dynamic pattern of motile cells.
We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cellsExpand
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Tumor-reprogrammed resident T cells resist radiation to control tumors
Successful combinations of radiotherapy and immunotherapy depend on the presence of live T cells within the tumor; however, radiotherapy is believed to damage T cells. Here, based on longitudinal inExpand
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The Role of the Class II Transactivator (CIITA) in MHC Class I and II Regulation and Graft Rejection in Kidney
Class II transactivator (CIITA) induces transcription of MHC class II genes, and induces class I in some cell lines. We examined the effect of CIITA deficiency on class I and II expression in mouseExpand
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Central Role for Interferon-γ Receptor in the Regulation of Renal MHC Expression
The role of the interferon-γ (IFN-γ) receptor 1 (IFN-γR1) was investigated in the regulation of MHC expression in kidney in the basal state, in response to potent inflammatory stimuli, and afterExpand
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