Lung Mechanics of Mechanically Ventilated Patients With COVID-19: Analytics With High-Granularity Ventilator Waveform Data
@article{Ge2020LungMO, title={Lung Mechanics of Mechanically Ventilated Patients With COVID-19: Analytics With High-Granularity Ventilator Waveform Data}, author={Huiqing Ge and Qing Pan and Yong Zhou and Peifeng Xu and Lingwei Zhang and Junli Zhang and Jun Yi and Changming Yang and Yuhan Zhou and Limin Liu and Wentao Bao}, journal={Frontiers in Medicine}, year={2020}, volume={7}, url={https://api.semanticscholar.org/CorpusID:221192135} }
The study for the first time described full trajectory of lung mechanics of patients with COVID-19 and showed that prone positioning was associated with improved compliance; higher plateau pressure and use of neuromuscular blockades were associated with lower risk of AI.
17 Citations
Respiratory Mechanics and Gas Exchange in Acute Respiratory Distress Syndrome Associated with COVID-19
- 2022
Medicine
The initial phase (the first 7 days) of ARDS associated with COVID-19 is characterized by higher values of Vt, RR and RMV, as well as lung compliance vs «typical» ARDS with almost identical PaO₂/FiO⁂ values.
Lower Driving Pressure and Neuromuscular Blocker Use Are Associated With Decreased Mortality in Patients With COVID-19 ARDS
- 2022
Medicine
In subjects with COVID-19 ARDS receiving mechanical ventilation, ΔP during the first 4 d of mechanical ventilation was independent associated with mortality and the short-term use of NMB facilitated lung-protective ventilation and was independently associated with decreased mortality.
Advances in Machine Learning for Mechanically Ventilated Patients
- 2025
Medicine, Computer Science
Machine learning shows great potential for improving intensive care quality and efficiency in mechanically ventilated patients, however, challenges like model interpretability, real-time performance, clinical and validation remain.
A Machine Learning Algorithm to Predict Hypoxic Respiratory Failure and risk of Acute Respiratory Distress Syndrome (ARDS) by Utilizing Features Derived from Electrocardiogram (ECG) and Routinely Clinical Data
- 2022
Medicine, Computer Science
Waveform-derived cardiorespiratory features, namely measures relating to variability and multi-scale entropy were robust and reliable features that predicted onset up to 36 hours before the clinical definition is met.
Multi-Modal Feature Fusion-Based Machine Learning to Detect Abnormal Mechanical Ventilation
- 2023
Medicine, Engineering
The fusion of multi-modal features is beneficial to the identification of abnormal ventilation and is promising to promote the application of machine learning models to detect abnormal ventilation in real clinical settings.
An archetypal model of a breathable air-circuit in an electro-pneumatic ventilator device
- 2022
Engineering, Medicine
Machine learning modeling of lung mechanics: Assessing the variability and propagation of uncertainty in respiratory-system compliance and airway resistance
- 2024
Medicine, Engineering
Virtual patient with temporal evolution for mechanical ventilation trial studies: A stochastic model approach
- 2023
Medicine, Engineering
Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
- 2022
Medicine
In patients with COVID-19 and moderate-to-severe ARDS, short course of NMBA treatment, applied early, did not significantly improve 90-day mortality and VFD and NMBAs should be indicated cautiously in this setting.
47 References
Variation of poorly ventilated lung units (silent spaces) measured by electrical impedance tomography to dynamically assess recruitment
- 2018
Engineering, Medicine
The variation of DSSs dynamically measured by EIT correlates well with lung recruitment measured using the P-V curve technique, and EIT might provide useful information to titrate personalized PEEP.
Patient-ventilator asynchrony during assisted mechanical ventilation
- 2006
Medicine
One-fourth of patients exhibit a high incidence of asynchrony during assisted ventilation, which is associated with a prolonged duration of mechanical ventilation and with excessive levels of ventilatory support.
Defining patient–ventilator asynchrony severity according to recurrence
- 2020
Medicine
Using PVA recurrence as a severity criterion has several advantages compared to proportion or clustering of PVA events, and it can be applied prospectively to select patients for further treatment, e.g., neuromuscular blockade.
Patient-ventilator asynchronies during mechanical ventilation: current knowledge and research priorities
- 2019
Medicine
Evolving concepts in asynchronies, lung crosstalk with other organs, and the difficulties of data management make more efforts necessary in this field.
Asynchronies during mechanical ventilation are associated with mortality
- 2015
Medicine
Asynchronies are common throughout MV, occurring in all MV modes, and more frequently during the daytime, when patients with an AI above the cutoff are admitted to intensive care unit beds.
Patient-ventilator asynchrony in adult critically ill patients.
- 2019
Medicine
Given the varying outcomes considered and the erratic results, it remains unclear whether asynchronies really affects patient outcome, and the relationship between asynchrony and outcome is causative or associative.
Impact of Lung Compliance on Neurological Outcome in Patients with Acute Respiratory Distress Syndrome Following Out-of-Hospital Cardiac Arrest
- 2020
Medicine
Lung compliance may be an early predictor of intact neurologic survival in patients with ARDS following cardiac arrest, and this observational study conducted in the emergency intensive care unit from January 2011 to April 2019 found this.
Lung recruitment in patients with the acute respiratory distress syndrome.
- 2006
Medicine
In ARDS, the percentage of potentially recruitable lung is extremely variable and is strongly associated with the response to PEEP, which may decrease ventilator-induced lung injury by keeping lung regions open that otherwise would be collapsed.
COVID-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome
- 2020
Medicine
It is found that hypercapnia was common in patients with COVID-19–associated ARDS while using low VT ventilation, and low VT may not be the best approach for all patients with ARDS, particularly those with a less severe decrease in respiratory system compliance and inadequacy of ventilation.