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Driving pressure and survival in the acute respiratory distress syndrome.
TLDR
It is found that ΔP was the ventilation variable that best stratified risk and decreases in ΔP owing to changes in ventilator settings were strongly associated with increased survival. Expand
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
TLDR
Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS. Expand
Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.
TLDR
Evaluating the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes found that higher levels were associated with improved survival among the subgroup of patients with ARDS, but lower levels were not associated withImproved hospital survival. Expand
Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study.
TLDR
Survival among mechanically ventilated patients depends not only on the factors present at the start of mechanical ventilation, but also on the development of complications and patient management in the intensive care unit. Expand
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material
TLDR
This panel addressed some of the limitations of the prior ARDS definition by incorporating current data, physiologic concepts, and clinical trials results to develop the Berlin definition, which should facilitate case recognition and better match treatment options to severity in both research trials and clinical practice. Expand
Patient-ventilator asynchrony during assisted mechanical ventilation
TLDR
One-fourth of patients exhibit a high incidence of asynchrony during assisted ventilation, which is associated with a prolonged duration of mechanical ventilation and with excessive levels of ventilatory support. Expand
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
TLDR
In patients with nonhypercapnic acute hypoxemic respiratory failure, treatment with high-flow oxygen, standard oxygen, or noninvasive ventilation did not result in significantly different intubation rates, and there was a significant difference in favor of high- flow oxygen in 90-day mortality. Expand
Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.
TLDR
In selected patients with acute exacerbations of chronic obstructive pulmonary disease, noninvasive ventilation can reduce the need for endotracheal intubation, the length of the hospital stay, and the in-hospital mortality rate. Expand
Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
TLDR
A strategy for setting PEEP aimed at increasing alveolar recruitment while limiting hyperinflation did not significantly reduce mortality, but it did improve lung function and reduced the duration of mechanical ventilation and theduration of organ failure. Expand
Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation.
TLDR
A randomized trial in three intensive care units in mechanically ventilated patients who met standard weaning criteria found a lower number of failures was found with PSV than with the other two modes, with the difference just reaching the level of significance. Expand
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