Hepatic uptake, intracellular accumulation and biliary secretion of 5-methyltetrahydrofolate.
@article{Wb1980HepaticUI,
title={Hepatic uptake, intracellular accumulation and biliary secretion of 5-methyltetrahydrofolate.},
author={Strum Wb and Li Hh},
journal={Research communications in chemical pathology and pharmacology},
year={1980},
volume={30},
pages={493-507},
url={https://api.semanticscholar.org/CorpusID:99035509}
}These studies indicate that hepatic uptake and biliary secretion of 5-methyltetrahydrofolate occurs by an energy-dependent, carrier-mediated process in which the coenzyme accumulates in the liver, is secreted into bile against a high concentration gradient and undergoes enterohepatic circulation.
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7 Citations
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Results indicate that 5-CH3-H4PteGlu and other derivatives are transported via cMOAT, which are the first endogenous substrates for c MOAT that do not contain glutathione, glucuronide, or sulfate moieties.
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The findings indicate that PteGlu competes with the bile reduced folates for the intestinal transport system and potentiates the decrease of plasma 5-methyltetrahydrofolic acid concentration induced by pyrimethamine in rats.
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Plasma homocysteine comes under both genetic and nutritional control. B vitamins and particularly folate are important factors in homocysteine metabolism. We have obtained reference intervals for…