Genetic control of hapten-reactive helper T-cell responses and its implications for the generation of augmented antitumor cytotoxic responses.

@article{Mizushima1985GeneticCO,
  title={Genetic control of hapten-reactive helper T-cell responses and its implications for the generation of augmented antitumor cytotoxic responses.},
  author={Yumiko Mizushima and Hiromi Fujiwara and Yasuyuki Takai and Gene M. Shearer and Toshiyuki Hamaoka},
  journal={Journal of the National Cancer Institute},
  year={1985},
  volume={74 6},
  pages={
          1269-73
        },
  url={https://api.semanticscholar.org/CorpusID:26019970}
}
The results indicate that the successful augmentation of syngeneic tumor immunity through T-T-cell interaction with the use of hapten-reactive helper T-cells can depend on selection of the appropriate haptenic reagent in an individual expressing a given major histocompatibility haplotype.

Augmented induction of CD8+ cytotoxic T‐cell response and antitumour resistance by T helper type 1‐inducing peptide

In tumour protection assays, immunization with Peptide‐25 and OVA resulted in the enhancement of CD8+ cytotoxic cell generation specific for OVA and the growth inhibition of EL‐4 thymoma expressing OVA peptide leading to the tumour rejection.

Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity

This work examined whether broadly expressed wild-type molecules in murine tumor cells eliciting humoral immunity contributed to the generation of CD8+ T cells and protective antitumor immune responses to unrelated tumor-specific antigens [mutated ERK2 (mERK2) and c-erbB2/HER/neu (HER2)].

Application of T Cell—T Cell Interaction to Enhanced Tumor-Specific Immunity Capable of Eradicating Tumor Cells in Vivo

The most compelling evidence for the existence of TATA comes from the study of chemically induced tumors of inbred rodents, which express neoantigens capable of immunizing syngeneic or autochthonous hosts against subsequent challenge with the same tumor.