Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis
@article{Baritaki2023CrossTalksBR, title={Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis}, author={Stavroula Baritaki and Apostolos Zaravinos}, journal={Cancers}, year={2023}, volume={15}, url={https://api.semanticscholar.org/CorpusID:264063615} }
The findings underscore the significant role of the interplay between YY1 and PEBP1 in cancer progression, influencing genomic changes, tumor immunity, or the tumor microenvironment, as well as opening new avenues for cancer therapy.
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114 References
Computational Analyses of YY1 and Its Target RKIP Reveal Their Diagnostic and Prognostic Roles in Lung Cancer
- 2022
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A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets
- 2022
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Understanding Mechanisms of RKIP Regulation to Improve the Development of New Diagnostic Tools
- 2022
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The main mechanisms that regulate the expression and activity of RKIP were discussed with the aim of identifying the link between the transcriptional, post-transcriptional and post- translational events in different tumour settings.
Functional Linkage of RKIP to the Epithelial to Mesenchymal Transition and Autophagy during the Development of Prostate Cancer
- 2018
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- 2023
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Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer.
- 2017
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A pan-cancer proteomic perspective on The Cancer Genome Atlas
- 2014
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R reverse-phase protein arrays are used to analyse 3,467 patient samples from 11 TCGA ‘Pan-Cancer’ diseases, providing a resource to study the prognostic and therapeutic potential of tumour proteins.
The biological implications of Yin Yang 1 in the hallmarks of cancer
- 2020
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Recent progress with respect to YY1 and its biological implications in the context of hallmarks of cancer is summarized.
Yin Yang 1 expression in human tumors
- 2010
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