Comprehensive analysis of gene expression and DNA methylation for human nasopharyngeal carcinoma

@article{Li2019ComprehensiveAO,
  title={Comprehensive analysis of gene expression and DNA methylation for human nasopharyngeal carcinoma},
  author={Hu Li and Fuling Wang and Liang Shan and Jun An and Minglei Liu and Wei Li and Jing-E. Zhang and Ping-ping Wu},
  journal={European Archives of Oto-Rhino-Laryngology},
  year={2019},
  pages={1-12},
  url={https://api.semanticscholar.org/CorpusID:195354127}
}
This study identified the novel NPC-related genes and biological pathways, shedding light on the potential molecular mechanisms of NPC, and helped elucidate the underlying mechanism of NPC and provide clues for therapeutic methods.
View on Springer
ncbi.nlm.nih.gov
3 Citations

3 Citations

Transcriptomic Analyses Reveal Gene Expression Profiles and Networks in Nasopharyngeal Carcinoma

Information is provided on the genes that may be involved in the development of NPC and suggests possible druggable targets and biomarkers for diagnosing and evaluating the prognosis of NPC.

Large-scale integration of DNA methylation and gene expression array platforms

The interpretation of EWAS results is limited in studies without multi-omic support and further research should identify genomic regions in which GE-associated DNAm is overrepresented, as well as question the validity of assuming a canonical cis DNAm-GE pathway.

Large-scale integration of DNA methylation and gene expression array platforms identifies both cis and trans relationships

The interpretation of EWAS results is limited in studies without multi-omic support and further research should identify genomic regions in which GE-associated DNAm is overrepresented.

26 References

Reexploring the possible roles of some genes associated with nasopharyngeal carcinoma using microarray-based detection.

The results suggested that the roles of BPAG1 and EGR1 are possibly different from those reported in previous NPC studies and are likely to be involved in the proliferation, apoptosis, invasion and metastasis of NPC.

Aberrant CpG‐methylation affects genes expression predicting survival in lung adenocarcinoma

Together, methylation aberrances regulate gene expression level during tumorigenesis and influence prognosis of LUAD patients.

Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma.

Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation

It is suggested that EZH2 upregulation is correlated with tumor aggressiveness and adverse patient outcomes in HNSCC.

Integrated Analysis of Long Noncoding RNA and mRNA Expression Profile in Advanced Laryngeal Squamous Cell Carcinoma

Significant evidence is provided that the identified lncRNAs and mRNAs are potential biomarkers in advanced LSCC for further future studies and qRT-PCR further validated the expression of these lnc RNAs andmRNAs.

The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest

The results demonstrate that DACT2 is frequently inactivated epigenetically by CpG methylation in NPC, while it inhibits NPC cell proliferation and metastasis via suppressing β-catenin/Cdc25c signaling.

MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1

Overall, miR-24 acts as a novel tumor suppressor in the development and progression of NPC through targeting FSCN1, which providing new insight into the mechanisms of NPC carcinogenesis and suggesting the possibility of mi R-24 as a therapeutic target.

Fascin1 expression predicts poor prognosis in patients with nasopharyngeal carcinoma and correlates with tumor invasion.

It is indicated that fascin1 expression is inversely correlated with NPC patient survival and directly correlated with the malignant status of NPC.

Journal of Translational Medicine Transcriptional Patterns, Biomarkers and Pathways Characterizing Nasopharyngeal Carcinoma of Southern China

A complete understanding of the pathogenesis of NPC in the context of global gene expression, transcriptional pathways and biomarker assessment remains to be elucidated.

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers

ADAMTS16 is identified as novel gene with cancer-specific promoter hypermethylation in CRC, LC and SCC patients implicating ADAM TS16 as potential biomarker for these tumors, and results provide evidence that ADAMTS 16 may have tumor suppressor properties.