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The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model
Voluntary exercise is the most effective intervention in upregulating the hippocampal BDNF level, and facilitating motor recovery, and Rats that exercised voluntarily also showed less corticosterone stress response than other groups.
Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
It is shown that cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection, suggesting that homozygosity forL-SIGN plays a protective role during SARS infection.
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
Sequence variation at the human ABO locus
- S. Yip
- BiologyAnnals of human genetics
- 1 January 2002
There is extensive sequence heterogeneity underlying the major ABO alleles that produce normal blood groups A, B, AB and O when in correct combination with other alleles and recombination is equally as important as point mutations in generating the genetic diversity of the ABO locus.
The TRP2 Allele of COL9A2 is an Age-Dependent Risk Factor for the Development and Severity of Intervertebral Disc Degeneration
This largest-ever population study using MRI to define DDD demonstrates for the first time that the Trp2 allele is a significant risk factor for the development and severity of degeneration.
Association of the Taq I Allele in Vitamin D Receptor With Degenerative Disc Disease and Disc Bulge in a Chinese Population
It is shown that the t allele of vitamin D receptor Taq I is associated with a high risk of degenerative disc disease and disc bulge developing, especially in individuals younger than 40 years.
Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma.
Whole-body vibration has no effect on neuromotor function and falls in chronic stroke.
The addition of the presently used whole-body vibration paradigm to a leg exercise protocol was no more effective in improving neuromotor performance and reducing the incidence of falls than leg exercises alone in chronic stroke patients who have mild to moderate motor impairments.
Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
Cardiac function is impaired and Foxo1/Bim‐related apoptotic signalling is up‐regulated in senescent heart Activation of SIRT1 deacetylase activity by resveratrol attenuates the Foxo1/Bim signalling…
Single-tube multiplex PCR-SSCP analysis distinguishes 7 common ABO alleles and readily identifies new alleles.
- S. Yip
- 15 February 2000
A new method based on the simultaneous amplification by polymerase chain reaction of 3 fragments from exon 6, and 5' and 3' ends of exon 7 of the ABO gene, followed by single-strand conformation polymorphism (SSCP) analysis is described, which is the simplest, quickest, and most informative method reported to date.