Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer.

@article{Shiohara1987AntitumorAO,
  title={Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer.},
  author={Tetsuo Shiohara and Gisela Moellmann and Kenneth Jacobson and Elizabeth Kuklinska and Nancy H. Ruddle and Adam Lerner},
  journal={Journal of immunology},
  year={1987},
  volume={138 6},
  pages={
          1979-86
        },
  url={https://api.semanticscholar.org/CorpusID:24130663}
}
Results indicate that autoreactive T cells can function in vivo as inhibitors of tumor growth.
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Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity.

The autoimmune and tumor-responsive TE2 cells, transplanted into the immune environment of the host, exhibit a specificity that is restricted toward neoplastic cells.

Autoreactive and heat shock protein 60-recognizing CD4+ T-cells show antitumor activity against syngeneic fibrosarcoma.

It is indicated that CD4+ autoreactive and hsp 60-recognizing T-cells show two types of antitumor activity: cytostasis and induction of tumor-specific cytotoxic T-lymphocytes in the presence of syngeneic macrophages and tumor necrosis factor synergized this activity.

Successful in vitro graft-versus-tumor effect against an Ia-bearing tumor using cyclosporine-induced syngeneic graft-versus-host disease in the rat.

These studies have demonstrated an in vitro GVT of syngeneic GVHD against an Ia-bearing tumor; the effector cell is a CTL of the OX8 phenotype specific for the class II MHC antigen.

Peripheral but not thymic T cells participate in an autoreactive T cell network.

Evidence for an involvement of T4+ cytotoxic T cells in tumor immunity.

Low doses of interleukin 2 induce bystander cell lysis by antigen‐specific CD4 inflammatory T cell clones in short‐term assay

It is proposed that killing of bystander targets by clone 5.8.8 is due to nonspecific cytolytic activity induced by the clone's own IL2 secreted in response to recognition of the specific target.

Origin and significance of autoreactive T cells.

Sensitivity of B16 melanoma sublines to lymphokine-activated killer cells as determined by 51Cr-release and clonogenic assays.

Preimmunization of mice with formalinized extracellular antigens of melanoma in combination with IL‐2 and surgical resection increased survival and tumor control in metastatic melanoma model

Combining preimmuni‐zation with FECA and IL‐2 and resection of local melanoma tumors decreased the mortality and the number of mice with local recurrence and metastatic melanomas tumors to the lungs.

Differential expression of lymphocyte function-associated antigen 1 (LFA-1) on epidermotropic and non-epidermotropic T-cell clones.

The results suggest that the presence of high levels of LFA-1 on T cells is absolutely necessary for their epidermotropic migration, but its up-regulation is neither necessary nor sufficient to trigger the epider Motorsportic migration.