Acetylcholine increases pulmonary blood flow in intact fetuses via endothelium-dependent vasodilation.

@article{Tiktinsky1992AcetylcholineIP,
  title={Acetylcholine increases pulmonary blood flow in intact fetuses via endothelium-dependent vasodilation.},
  author={M H Tiktinsky and James J Cummings and Frederick C. Morin},
  journal={The American journal of physiology},
  year={1992},
  volume={262 2 Pt 2},
  pages={
          H406-10
        },
  url={https://api.semanticscholar.org/CorpusID:44476862}
}
It is concluded that acetylcholine increases pulmonary blood flow in the fetal lamb via the release of EDRF derived from L-Arg, and it is speculated that endothelium-dependent vasodilation may play a role in the increase in pulmonaryBlood flow at birth.
View on PubMed
doi.org
48 Citations
Highly Influential Citations
2
Background Citations
6
Methods Citations
2

48 Citations

Mechanisms of Adrenomedullin-Induced Increase of Pulmonary Blood Flow in Fetal Sheep

It is suggested that in the fetal pulmonary circulation, the adrenomedullin-induced increase in pulmonary blood flow depends largely on nitric oxide release and partly on KATP channel activation, and does not involve the CGRP receptor or a cyclooxygenase-mediated mechanism.

Maturation of the Contractile Response and Its Endothelial Modulation in Newborn Porcine Intrapulmonary Arteries

It is suggested that excessive reactivity in the newborn pulmonary vasculature may be due to immaturity of mechanisms determining endothelium-dependent arterial relaxation, but not to an excessive contractile response.

The Effects of cGMP on Fetal Sheep Pulmonary Blood Flow and Lung Liquid Production

It is demonstrated that 8-bromo-cGMP decreases lung liquid production and increases pulmonary blood flow in near term fetal sheep, and it is possible that a common transduction pathway involving cGMP may be responsible for lung liquid reduction and elevation of pulmonaryBlood flow at birth.

Mechanisms of calcitonin gene-related peptide-induced increases of pulmonary blood flow in fetal sheep.

In the fetal pulmonary circulation, CGRP increases pulmonary blood flow not only through its specific receptor but also, in part, through nitric oxide release and K(ATP) channel activation.

Differential responses of ovine intrapulmonary arteries and veins to acetylcholine.

Regulation of vasodilator synthesis during lung development.

NO supports right ventricular flow dominance and whole body O(2) utilization in midgestation fetal lambs.

It is suggested that, in midgestation fetal lambs, NO supports an RV flow dominance, whole body O2 utilization, and the maintenance of a near-equal fetoplacental blood flow distribution.

Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility.

Heterogeneity of fetal pulmonary arteries and veins in response to long-term high-altitude hypoxia is demonstrated and a likely common mechanism downstream of NO in fetal pulmonary vessel response to chronic hypoxIA in utero is suggested.

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

Zaprinast pretreatment significantly enhances the effect of sodium nitroprusside on isolated pulmonary arteries, as well as theeffect of inhaled NO at 6 ppm in newborn lambs with persistent pulmonary hypertension, indicating a true synergistic effect.

Nitric Oxide and the Perinatal Pulmonary Circulation

Since the postnatal survival of the fetus depends on a very rapid and appropriate establishment of pulmonary blood flow and alveolar ventilation, a remarkable adaptation of the pulmonary circulation must occur with the initiation of respiration, and the circulatory pattern must change toward the adult pattern.