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HDAC8 mutations in Cornelia de Lange Syndrome affect the cohesin acetylation cycle

HDRAC8 is identified as the vertebrate SMC3 deacetylase, as well as loss-of-function HDAC8 mutations in six CdLS probands, which results in increased SMC 3 acetylation and inefficient dissolution of the ‘used’ cohesin complex released from chromatin in both prophase and anaphase.
Nature (opens in a new tab)

PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.

PubMed (opens in a new tab)

Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

Elsevier (opens in a new tab)

Eukaryotic replisome components cooperate to process histones during chromosome replication.

PubMed (opens in a new tab)

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

A role for compromised cohesin functions in myeloid leukemogenesis is suggested by the growth of leukemic cell lines harboring a mutation in RAD21 or having severely reduced expression of RAD21 and STAG2 being suppressed by forced expression of wild-type RAD21 (Kasumi-1 cells and MOLM-13 cells).
Nature (opens in a new tab)

The dynamics of genome replication using deep sequencing

It is shown that the replication profiles of haploid and diploid cells are indistinguishable, indicating that both cell types use the same cohort of origins with the same activities, which provides a high-resolution resource and methodological framework for studying genome biology.
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Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells

The Smc5/6 complex plays a critical role in processing DNA replication and is indispensable for sister chromatid assembly and faithful segregation in mitosis.
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Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2

Elsevier (opens in a new tab)

Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.

PubMed (opens in a new tab)

The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

Using high-resolution ChIP-sequencing, it is shown that the chromosomal localization of Smc5/6 predicts the presence of the chromatid segregation-inhibiting entities which accumulate in top2-4 mutated cells, and indicates that, at least when Top2 is inhibited, Smc 5/6 facilitates their resolution.
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