diBAC oxonol dyes inhibit the electrogenic Na/bicarbonate cotransporter NBCe1‐A
- Xiaofen LiuJennifer B. WilliamsBrandon R. SumpterM. O. Bevensee
- 1 April 2007
Chemistry, Medicine
Na/HCO3 cotransporters (NBCs) are members of a superfamily of HCO3− transporters involved in intracellular pH regulation, HCO3− secretion/reabsorption, and ion transport. Specific inhibitors of the…
Inhibition of the Na/Bicarbonate Cotransporter NBCe1-A by diBAC Oxonol Dyes Relative to Niflumic Acid and a Stilbene
- Xiaofen LiuJennifer B. WilliamsBrandon R. SumpterM. O. Bevensee
- 20 June 2007
Chemistry, Medicine
The mechanism of diBAC inhibition of NBCe1 appears similar to that previously reported for AE1 and competes with DIDS but not appreciably with Na+ or HCO3− for binding.