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ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease, and highlights the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings.
Springer Nature (opens in a new tab)

Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study

Findings support the existence of distinct developmental pathways to CU, and focus on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously implicated in CU.
Nature (opens in a new tab)

Childhood maltreatment and DNA methylation: A systematic review.

Findings generally support an association between childhood maltreatment and altered patterns of DNAm, but factors such as the lack of longitudinal data, low comparability across studies as well as potential genetic and 'pre-exposure' environmental confounding currently limit the conclusions that can be drawn.
PubMed (opens in a new tab)

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Summary Background Childhood maltreatment is associated with poor mental and physical health. However, the mechanisms of gene–environment correlations and the potential causal effects of childhood…
PubMed (opens in a new tab)

The role of epigenetic modifications in neurodevelopmental disorders: A systematic review

Overall, evidence of an association between epigenetic modifications and ASD or ADHD should be considered preliminary and based on studies suffering from numerous caveats and the need for carefully designed investigations and for greater homogeneity is highlighted.
Wolters Kluwer (opens in a new tab)

Epigenetic profiling of ADHD symptoms trajectories: A prospective, methylome-wide study

It is found that DNA methylation at birth differentiated ADHD trajectories across multiple genomic locations, including probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated in ADHD), ST3GAL3 (linked to intellectual disability) and PEX2 (related to perixosomal processes).
Wolters Kluwer (opens in a new tab)

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

A developmental role for DNA methylation that extends beyond birth into late adolescence and has implications for understanding life-long health and disease is supported.
PDF (opens in a new tab)

Prenatal unhealthy diet, insulin‐like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early‐onset conduct problems

Preventing ‘unhealthy diet’ in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.
Wolters Kluwer (opens in a new tab)

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication

Combining data from two independent population-based samples in an epigenome-wide meta-analysis indicates that there are no large effects of prenatal maternal stress exposure on neonatal DNA methylation.
Taylor & Francis (opens in a new tab)

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

A link between i-ePGS and child and adolescent mental health is supported and externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects.
Cambridge Press (opens in a new tab)
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