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Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals.

In a population of cognitively unimpaired adults with increased risk of AD, long-term exposure to air pollution was associated with higher levels in biomarkers of AD pathology, reinforcing the role of air pollution as an environmental risk factor for AD.
PubMed (opens in a new tab)

New suggestive genetic loci and biological pathways for attention function in adult attention‐deficit/hyperactivity disorder

The conceptualization of attention function as a potential endophenotype for studying the molecular basis of adult ADHD is reinforced, and several of the pathways nominally associated with the CPT outcomes are relevant for ADHD.
Wiley (opens in a new tab)

Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences.

Individuals exposed to childhood abuse are more likely to report positive psychotic-like experiences than did individuals carrying the Val/Val genotype, suggesting the observed gene-environment interaction effect may be partially responsible for individual variation in response to Childhood abuse.
PubMed (opens in a new tab)

Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts

Prenatal exposure to acetaminophen was associated with ASC or ADHD symptoms and boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys.
Springer Nature (opens in a new tab)

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population.

The present findings indicate that the neurobiological manifestation of polygenic susceptibility for ADHD, educational attainment, and intelligence involve early morphologic differences in caudate and total brain volumes in childhood.
PubMed (opens in a new tab)

Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study

DNA methylation levels at IGF2 and IGF2BP1 were examined in a sample of 34 adult monozygotic twins informative for obstetric complications and cognitive performance and a link was detected between DNA methylation Levels of two CpG sites in the IGF2 BP1 gene and both BW and adult WM performance.
PDF (opens in a new tab)

Traffic-Related Air Pollution, APOE ε4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain)

PAHs, EC, and NO2 were associated with higher behavior problem scores, smaller reductions in inattentiveness over time, and smaller caudate volume in APOE ε4 allele carriers in the study population, and corresponding associations were weak or absent among ε 4 noncarriers.
PubMed (opens in a new tab)

Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Evidence is found that DNA methylation at birth is associated with ADHD, and future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways.
Springer Nature (opens in a new tab)

Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children

Prenatal exposure to PM2.5 may be associated with CC volume decrease in children and the consequences might be an increase in behavioral problems.
PubMed (opens in a new tab)

Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

Individuals exposed to childhood adversity are more likely to report psychotic experiences and the findings indicate that this association is not due to genetic confounding.
Cambridge Press (opens in a new tab)
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