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BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis.

Four new chromone glycosides allo-aloeresin D (2) and 8 showed significant inhibitory activity against BACE1 (beta-secretase) with IC (50) values of 39.0 and 20.3 %, respectively, in B103 neuroblastoma cells at 30 ppm.
PubMed (opens in a new tab)

Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells.

The findings demonstrate that KF may be a useful candidate for pharmacological therapies that can prevent and treat neurodegenerative diseases such as Alzheimer's disease (AD), and revealed that the neuroprotective effects of KF are a result of the regulation of the expression levels of proteins.
PubMed (opens in a new tab)

Anti-inflammatory Effects of Oleanolic Acid on LPS-Induced Inflammation In Vitro and In Vivo

It is suggested that OA has anti-inflammatory effects by inhibiting hyperpermeability, the expression of CAMs, and the adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapeutic agent for vascular inflammatory diseases.
Springer Nature (opens in a new tab)

Isolation, Synthesis, and Antisepsis Effects of a C-Methylcoumarinochromone Isolated from Abronia nana Cell Culture.

Results suggested that a new C-methylcoumarinochromone isolated from Abronia nana suspension cultures might have potential therapeutic activity against various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
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Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix…

The analytical method developed could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.
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Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death

Quercetin had a protective effect by reducing both intracellular ROS overproduction and glutamate-mediated Ca2+ influx, and suppressed phosphorylation of MAPKs, which may be useful for preventing or treating neurodegenerative disorders.
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Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction.

It is demonstrated that isoliquiritigenin isolated from Glycyrrhiza uralensis (Gu), one of the most frequently prescribed oriental herbal medicines, protected HT22 hippocampal neuronal cells from glutamate-induced oxidative stress and the results suggest that ISL may protect against mitochondrial dysfunction by limiting glutamate- induced oxidative stress.
PubMed (opens in a new tab)

Barrier protective effects of rosmarinic acid on HMGB1‐induced inflammatory responses in vitro and in vivo

High mobility group box 1 (HMGB1) protein is a crucial cytokine that mediates response to infection, injury, and inflammation and RA should be viewed as a candidate therapeutic agent for the treatment of various inflammatory diseases via inhibition of the HMGB1 signaling pathway.
Wiley (opens in a new tab)

Syringin from stem bark of Fraxinus rhynchophylla protects Aβ(25–35)-induced toxicity in neuronal cells

Results suggest that F. rhynchophylla and syringin are expected to be useful for preventing Aβ(25–35)-induced neuronal cell damage and the neuroprotective effect of syring in seemed to be originated from the reduction of apoptosis.
Springer Nature (opens in a new tab)

Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells.

Liquiritigenin effectively reduced glutamate-induced early apoptosis through inhibition of Ca(2+) influx, intracellular reactive oxygen species (ROS) production, and lipid peroxidation, and suppressed not only the release of apoptosis-inducing factor (AIF), but also activation of mitogen-activated protein kinases (MAPKs).
PubMed (opens in a new tab)
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