Learn More
BACKGROUND Human pulmonary arterial hypertension (PAH) is characterized by proliferation of vascular smooth muscle and, in its more severe form, by the development of occlusive neointimal lesions. However, few animal models of pulmonary neointimal proliferation exist, thereby limiting a complete understanding of the pathobiology of PAH. Recent studies of(More)
INTRODUCTION Left untreated, malignant pleural mesothelioma (MPM) is associated with uniformly poor prognosis. Better survival has been reported with surgery-based multimodality therapy, but to date, no trial has demonstrated survival benefit of surgery over other therapies. We evaluated whether cancer-directed surgery influenced survival independently from(More)
Paeoniae Radix, a traditional herbal medicine, has been used in antispasmodic action, alleviating pain, and activating circulation. The aim of this study was to evaluate the pharmacokinetics (PKs) of paeoniflorin in healthy Korean subjects and develop an analytical method for the quantification of paeoniflorin in human plasma. This was an open-label,(More)
We are reporting on a case of a 41-year-old woman who presented with metastatic gastroesophageal junction cancer and who achieved prolonged survival with a multimodal treatment approach. After initially experiencing robust response to chemotherapy, she was treated for distant recurrence with palliative radiation to the gastrohepatic and supraclavicular(More)
The energy performance of buildings depends on how effectively the building envelope responds to climate. Architects, therefore, need to design building envelopes with the consideration of local climate characteristics in the early design stage. Simplified formulas were used that evaluate the heating and cooling energy demand of building envelopes, which(More)
In order to evaluate the thermal and lighting energy performance of a kinetic façade using external movable shading devices, it is important to consider the operation of the shading devices since it can influence the performance significantly. This study proposes a calculation methodology which assesses the performance of the movable shading devices with(More)
In this study, a sensitive, accurate and cost-effective ultra-performance liquid chromatography-tandem mass spectrometric method was developed using a new clean-up process for the quantification of leuprolide in rat plasma. Chromatography was carried on a HALO peptide ES-C18 column using water and acetonitrile (containing 1% acetic acid) as the mobile phase(More)