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Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans

It is shown that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress reactivity, and its genomic location, a CpG island shore within an H3K27ac enhancer mark, and the correlation between methylation in the blood and prefrontal cortex provide further evidence that KITLG methylation is functionally relevant for the programming of stress reactsivity in the human brain.
Springer Nature (opens in a new tab)

Association of Trauma Type, Age of Exposure, and Frequency in Childhood and Adolescence With Psychotic Experiences in Early Adulthood

Findings are consistent with the thesis that trauma could have a causal association with psychotic experiences; if so, identification of modifiable mediators is required to inform prevention strategies.
Wolters Kluwer (opens in a new tab)

Time-dependent changes in altruistic punishment following stress.

It is found that stress caused a bi-directional effect on altruistic punishment, with decreased rejection rates in the late aftermath of stress in response to ambiguous 30% offers, and the importance of time as a factor in simple, real-life economic decisions in a stressful social context is underscore.
PubMed (opens in a new tab)

Associations of adverse childhood experiences with educational attainment and adolescent health and the role of family and socioeconomic factors: A prospective cohort study in the UK

This study demonstrates associations between ACEs and lower educational attainment and higher risk of depression, drug use, and smoking, and finds no evidence that socioeconomic factors modified the associations of ACEs with educational or health outcomes.
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Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics

The associations of higher maternal body mass index and larger birth size with greater gestational age acceleration may imply that maternal overweight and obesity is associated with more rapid development of the fetus in utero.
Springer Nature (opens in a new tab)

Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC)

ACE constructs, derived using a pragmatic approach to handle the high dimensional ALSPac data, can be used in future analyses on childhood adversity in ALSPAC children.
PDF (opens in a new tab)

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment

The importance of SKA2 for cortisol stress responsivity and the development of PTSD is established and the previously published suicide prediction rule significantly predicted post-deployment PTSD symptoms is found.
Nature (opens in a new tab)

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

A developmental role for DNA methylation that extends beyond birth into late adolescence and has implications for understanding life-long health and disease is supported.
PDF (opens in a new tab)

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

In this prospective population-based study of UK children, cumulative ACE exposure, emotional abuse, and physical abuse between age 0 and 14’years were each associated with Horvath-estimated DNA methylation age acceleration at age 17 years in girls but not in boys, and Associations were also null between ACE and cortisol, and cortisol and DNA methylated age acceleration.
Springer Nature (opens in a new tab)

DNA methylation signatures of mood stabilizers and antipsychotics in bipolar disorder.

Psychiatric drugs influence DNA methylation patterns over and above cell type composition in bipolar disorder and are not only an important confounder in psychiatric epigenetics but may also inform on the biological mechanisms underlying drug efficacy.
PubMed (opens in a new tab)
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