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Stress and the brain: from adaptation to disease
TLDR
New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.
Brain corticosteroid receptor balance in health and disease.
TLDR
The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.
Learning under stress: how does it work?
The neuro-symphony of stress
TLDR
Together, the effects of individual mediators on neuronal function and plasticity are integrated, and emerging evidence suggests that there is crosstalk between them that enables fine-tuned responses to diverse challenges.
Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone.
TLDR
It is reported that corticosterone also rapidly and reversibly changes hippocampal signaling, and would allow the brain to change its function within minutes after stress-induced elevations of corticosteroid levels, in addition to responding later through gene-mediated signaling pathways.
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
TLDR
This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Stress effects on memory: An update and integration
Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress
TLDR
It is suggested that maternal effects may modulate optimal cognitive functioning in environments varying in demand in later life, with offspring of high and low LG mothers showing enhanced learning under contexts of low and high stress, respectively.
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