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viral terminase complex

Known as: viral terminase complex location 
A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance
ABSTRACT The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the use of antiviral agents that… Expand
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2016
2016
Impact of glycoprotein B genotype and naturally occurring ORF UL56 polymorphisms upon susceptibility of clinical human cytomegalovirus isolates to letermovir.
Letermovir is a novel anti-HCMV drug in Phase III development that targets the UL56 subunit of the viral terminase complex. In… Expand
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2015
2015
Phenotypic characterization of two naturally occurring human Cytomegalovirus sequence polymorphisms located in a distinct region of ORF UL56 known to be involved in in vitro resistance to letermovir.
Letermovir is a new drug in Phase 3 clinical development for the prevention of human Cytomegalovirus (HCMV) infections in… Expand
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2013
2013
The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89.
Cleavage of human cytomegalovirus (HCMV) genomes as well as their packaging into capsids is an enzymatic process mediated by… Expand
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2013
2013
Letermovir Treatment of Human Cytomegalovirus Infection Antiinfective Agent.
Novel therapies are urgently needed for the management of cytomegalovirus (CMV) disease in high-risk patients. Currently licensed… Expand
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2013
2013
The human cytomegalovirus UL 51 protein is essential for viral genome cleavage-1 packaging and interacts with the terminase subunits pUL 56 and pUL 89 2 3
 
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Highly Cited
2011
Highly Cited
2011
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.
Human cytomegalovirus (HCMV) remains the leading viral cause of birth defects and life-threatening disease in transplant… Expand
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Highly Cited
2011
Highly Cited
2011
First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246.
We report the first case of cytomegalovirus (CMV) disease treated with AIC246, a novel anti-CMV compound which targets the viral… Expand
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