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vidofludimus

Known as: 2-(3-fluoro-3'-methoxybiphenyl-4-carbamoyl)cyclopent-1-enecarboxylic acid, 4SC-101 
National Institutes of Health

Papers overview

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2020
2020
BACKGROUND Inhibition of dihydroorotate dehydrogenase (DHODH) is an established mechanism for the treatment of relapsing… Expand
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2020
2020
Background and Objective Vidofludimus is a potent and selective inhibitor of human mitochondrial enzyme dihydroorotate… Expand
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2019
2019
The dihydroorotate dehydrogenase (DHODH) inhibitors leflunomide and teriflunomide are immunomodulatory agents approved to treat… Expand
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2013
2013
BACKGROUND Vidofludimus (SC12267) is a novel oral immunomodulator inhibiting dihydroorotate dehydrogenase (DHODH) and the… Expand
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2012
2012
Vidofludimus (Vido) is a novel oral immunomodulatory drug that inhibits dihydro-orotate dehydrogenase and lymphocyte… Expand
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2012
2012
Background 4SC-101 is a novel dihydroorotate dehydrogenase inhibitor and a blocker of interleukin (IL)-17 secretion with… Expand
2011
2011
IL-17 Secretion: Murine Splenocytes Vidofludimus Inhibits the Nuclear Binding of STAT3 in a Dose Dependent Fashion: Murine… Expand
Highly Cited
2010
Highly Cited
2010
Background: Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for… Expand
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2010
2010
Immunosuppressive treatments of systemic lupus (SLE) remain associated with significant toxicities; hence, compounds with better… Expand
2010
2010
Immunosuppressive treatments of systemic lupus (SLE) remain associated with significant toxicities; hence, compounds with better… Expand
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