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verubecestat

Known as: N-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic S-OxidesThiadiazines

Narrower (1)

MK-8931

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Quantification and pharmacokinetic property of verubecestat an BACE1 inhibitor in rat plasma.
In the present study, an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) approach was designed to… 
2019
2019
Lessons that can be learnt from the failure of verubecestat in Alzheimer’s disease
ABSTRACT Introduction: The amyloid-beta (Aβ) cascade hypothesis is that reducing Aβ levels in the brain will be beneficial in… 
2019
2019
Cariprazine Benefits Patients With Bipolar Depression.
  • A. Slomski
  • Journal of the American Medical Association (JAMA…
  • 2019
  • Corpus ID: 195356996
2018
2018
Verubecestat in Mild-to-Moderate Alzheimer Disease
Cleavage of amyloid precursor protein by beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) leads to amyloid-beta (A… 
2018
2018
SympoSia S 1-APECS TRIAL OF THE BACE 1 INHIBITOR VERUBECESTAT FOR PRODROMAL ALZHEIMER ’ S DISEASE
Introduction: The amyloid hypothesis proposes that Aβ peptides are intimately involved in the etiology of Alzheimer’s disease (AD… 
2018
2018
Discovery and Chemical Development of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer’s Disease
2018
2018
Fewer Patients with Breast Cancer Require Chemotherapy 2 . Plasma 25-Hydroxyvitamin
  • 2018
  • Corpus ID: 53119910
1. Fewer Patients with Breast Cancer Require Chemotherapy 2. Plasma 25-Hydroxyvitamin D Concentration Is Associated Inversely… 
2018
2018
Faculty Opinions recommendation of The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
  • A. BudsonJ. Weller
  • Faculty Opinions – Post-Publication Peer Review…
  • 2018
  • Corpus ID: 80903422
Review
2016
Review
2016
Title : Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer ’ s disease patients
iRGD (internalizing RGD) with high affinity to αν integrins was reported to enhance tumor penetrability by binding to neuropilin… 
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