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vancomycin biosynthetic process

Known as: vancomycin biosynthesis, vancomycin synthesis, vancomycin anabolism 
The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C… Expand
National Institutes of Health

Papers overview

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2015
2015
Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics.
Understanding the mechanisms underpinning glycopeptide antibiotic biosynthesis is key to the future ability to reinvent these… Expand
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2014
2014
Bis-chlorination of a hexapeptide-PCP conjugate by the halogenase involved in vancomycin biosynthesis.
Vancomycin is an important nosocomial antibiotic containing a glycosylated, cross-linked and doubly chlorinated heptapeptide… Expand
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2013
2013
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis
  • L. Xu, He Huang, +12 authors Wei Zhao
  • BMC Genomics
  • 2013
    • Corpus ID: 2818615
BackgroundAmycolatopsis orientalis is the type species of the genus and its industrial strain HCCB10007, derived from ATCC 43491… Expand
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2011
2011
Role of MbtH-like Proteins in the Adenylation of Tyrosine during Aminocoumarin and Vancomycin Biosynthesis*
Background: l-Tyrosine adenylation is a key step in aminocoumarin antibiotic and vancomycin biosynthesis. Results: Several but… Expand
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2008
2008
New insights into the first oxidative phenol coupling reaction during vancomycin biosynthesis.
OxyB catalyzes the first oxidative phenol coupling reaction in vancomycin biosynthesis. OxyB is a P450 hemoprotein whose activity… Expand
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2008
2008
Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis.
OxyB is a cytochrome P450 enzyme that catalyzes the first oxidative phenol coupling reaction during vancomycin biosynthesis. The… Expand
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Highly Cited
2007
Highly Cited
2007
Oxidative phenol coupling reactions catalyzed by OxyB: a cytochrome P450 from the vancomycin producing organism. implications for vancomycin biosynthesis.
OxyB is a cytochrome P450 enzyme that catalyzes the first phenol coupling reaction during the biosynthesis of vancomycin-like… Expand
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Highly Cited
2007
Highly Cited
2007
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis
Enzyme-catalysed oxidations are some of the most common transformations in primary and secondary metabolism. The vancomycin… Expand
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2003
2003
Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis.
Gene inactivation studies point to the involvement of OxyC in catalyzing the last oxidative phenol coupling reaction during… Expand
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Highly Cited
2002
Highly Cited
2002
Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis*
Gene-inactivation studies point to the involvement of OxyB in catalyzing the first oxidative phenol coupling reaction during… Expand
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