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valilactone

Known as: 5-(N-formyl-L-valinyloxy)-2-hexyl-3-hydroxydecanoic lactone, L-Valine, N-formyl-, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)hexyl ester, (2S-(2alpha(R*),3beta))- 
 
National Institutes of Health

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Lactones

Papers overview

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2008
2008
Synthesis of novel beta-lactone inhibitors of fatty acid synthase.
Fatty acid synthase (FAS) is necessary for growth and survival of tumor cells and is a promising drug target for oncology. Here… Expand
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2006
2006
Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase.
Concise syntheses of orlistat (Xenical), a two-carbon transposed orlistat derivative, and valilactone are described that employ… Expand
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2006
2006
An expeditious enantioselective total synthesis of valilactone.
The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic… Expand
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2006
2006
An expeditious enantioselective total synthesis of valilactone
The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic… Expand
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1994
1994
Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation.
Panclicins A-E are novel and potent pancreatic lipase inhibitors produced by Streptomyces sp. NR 0619. Their structures have been… Expand
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1987
1987
Valilactone, an inhibitor of esterase, produced by actinomycetes.
brane, had important effects on cellular functions1^. These inhibitors included esterastin which inhibited esterase and… Expand
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