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vabicaserin

National Institutes of Health

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Heterocyclic Compounds, 4 or More Rings

Papers overview

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2019
2019
Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays.
2015
2015
The design , synthesis and evaluation of tetra-substituted pyridines as potent 5-HT 2 C receptor agonists
A series of pyrido[3,4-d]azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340… 
2014
2014
Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model
A quantitative systems pharmacology model that combines in vitro/preclinical neurophysiology data, human imaging data, and… 
2013
2013
Asymmetric synthesis of vabicaserin via oxidative multicomponent annulation and asymmetric hydrogenation of a 3,4-substituted quinolinium salt.
An efficient, asymmetric synthesis of the 5-HT2C agonist vabicaserin in four chemical steps and 54% overall yield from… 
2011
2011
A 6-week Randomized, Double-blind, Placebo-controlled, Comparator Referenced, Multicenter Trial of Vabicaserin in Subjects With Acute Exacerbation of Schizophrenia
Vabicaserin has been developed for the treatment of schizophrenia. It was evaluated in this randomized, double- blind, placebo… 
2010
2010
Metabolism of Vabicaserin in Mice, Rats, Dogs, Monkeys, and Humans
Vabicaserin is a potent 5-hydroxytryptamine2C agonist that is currently being developed for the treatment of the psychotic… 
2008
2008
An old dog learns a new trick: regulation of peripheral glucose homeostasis by the serotonin (5-HT)2C receptor.
The American Diabetes Association has determined that diabetes costs the United States more than $170 billion per year in… 
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