ustekinumab

Known as: Immunoglobulin G1, Anti-(Human Interleukin-12 Subunit beta (IL-12B, CLMF p40, NKSF2)) (Human Monoclonal CNTO 1275 gamma1-chain), Disulfide with Human Monoclonal CNTO 1275 kappa-chain, Dimer, Ustekinumab [Chemical/Ingredient] 
An orally available, human, IgG1kappa, monoclonal antibody directed against the p40 protein subunit of both interleukin-12 (IL-12) and IL-23, with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2017
010020020072017

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Many patients with psoriasis develop psoriatic arthritis, a chronic inflammatory disease that afflicts peripheral… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against interleukin-12 and… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Biologic agents offer a range of new therapeutic options for patients with psoriasis; however, the relative benefit… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Since some patients with psoriatic arthritis do not respond to typical drug treatments, alternatives are needed… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Interleukins 12 and 23 have important roles in the pathophysiology of psoriasis. We assessed ustekinumab, a human… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Ustekinumab, a human monoclonal antibody against interleukins 12 and 23, has shown therapeutic potential for psoriasis… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Interleukin-12 and interleukin-23 are inflammatory cytokines implicated in Crohn's disease pathophysiology… (More)
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Highly Cited
2008