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tryptamine-4,5-dione

Known as: 4,5-diketotryptamine 
National Institutes of Health

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2 relations

Broader (2)

IndolequinonesTryptamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword
Abstract Serotonin (5-hydroxytryptamine) is a putative substrate for myeloperoxidase, which may convert it into the reactive… 
2012
2012
Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione.
Serotonin (5-hydroxytryptamine; 5HT) is a favorable substrate for myeloperoxidase and is likely to be oxidized by this heme… 
2009
2009
Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione.
During inflammatory events, neutrophils and platelets interact to release a variety of mediators. Neutrophils generate superoxide… 
2004
2004
Reactions of the putative neurotoxin tryptamine-4,5-dione with L-cysteine and other thiols.
Tryptamine-4,5-dione (1) is formed by oxidation of 5-hydroxytryptamine by reactive oxygen and reactive nitrogen species. Dione 1… 
2002
2002
Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione.
A transient energy impairment with resultant release and subsequent reuptake of 5-hydroxytryptamine (5-HT) and NMDA receptor… 
2001
2001
A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine.
Tryptamine-4,5-dione (T-4,5-D) is formed as a result of oxidation of 5-hydroxytryptamine by superoxide (O(2)(-)(*), nitric oxide… 
1999
1999
Tryptamine-4,5-dione, a putative endotoxic metabolite of the superoxide-mediated oxidation of serotonin, is a mitochondrial toxin: possible implications in neurodegenerative brain disorders.
The release and subsequent reuptake of 5-hydroxytryptamine (5-HT) and cytoplasmic superoxide (O2-*) generation have both been… 
Highly Cited
1998
Highly Cited
1998
Oxidation of serotonin by superoxide radical: implications to neurodegenerative brain disorders.
Many new lines of evidence implicate both superoxide anion radical (O2*-) and biogenic amine neurotransmitters in the… 
1991
1991
Modification of Brain Guanine Nucleotide‐Binding Regulatory Proteins by Tryptamine‐4,5‐Dione, a Neurotoxic Derivative of Serotonin
Abstract: We have recently characterized a novel oxidation product of serotonin (5‐hydroxytryptamine, 5‐HT), tryptamine‐4,5‐dione… 
1989
1989
Increased serotonin efflux by a partially oxidized serotonin: tryptamine-4,5-dione.
A partially oxidized serotonin (5-HT) was synthesized electrochemically from 5-HT in an acidic solution. This compound was… 
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