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tryptamine-4,5-dione

Known as: 4,5-diketotryptamine 
National Institutes of Health

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2 relations

Broader (2)

IndolequinonesTryptamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword
Abstract Serotonin (5-hydroxytryptamine) is a putative substrate for myeloperoxidase, which may convert it into the reactive… 
2012
2012
Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione.
Serotonin (5-hydroxytryptamine; 5HT) is a favorable substrate for myeloperoxidase and is likely to be oxidized by this heme… 
2004
2004
Reactions of the putative neurotoxin tryptamine-4,5-dione with L-cysteine and other thiols.
Tryptamine-4,5-dione (1) is formed by oxidation of 5-hydroxytryptamine by reactive oxygen and reactive nitrogen species. Dione 1… 
2003
2003
Stability of the putative neurotoxin tryptamine-4,5-dione.
Tryptamine-4,5-dione (1) is formed by oxidation of the neurotransmitter 5-hydroxytryptamine by reactive oxygen and reactive… 
2002
2002
Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione.
A transient energy impairment with resultant release and subsequent reuptake of 5-hydroxytryptamine (5-HT) and NMDA receptor… 
2001
2001
A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine.
Tryptamine-4,5-dione (T-4,5-D) is formed as a result of oxidation of 5-hydroxytryptamine by superoxide (O(2)(-)(*), nitric oxide… 
1997
1997
5‐Hydroxy‐3‐Ethylamino‐2‐Oxindole Is Not Formed in Rat Brain Following a Neurotoxic Dose of Methamphetamine: Evidence that Methamphetamine Does Not Induce the Hydroxyl Radical‐Mediated Oxidation of…
Abstract: Oxygen radicals have been implicated in the neurodegenerative and other neurobiological effects evoked by… 
1996
1996
Neurotoxicity of free-radical-mediated serotonin neurotoxin in cultured embryonic chick brain neurons.
1992
1992
Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione
1988
1988
Further insights into the oxidation chemistry of 5-hydroxytryptamine.
An important product of electrochemical oxidation of 5-hydroxytryptamine (5-HT) in acid solution is the purple compound… 
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